The Minnesota Vikings visit the Detroit Lions on Sunday, November 1, with DraftKings Sportsbook listing Detroit as a three-point favorite.
Minnesota's defense allows
just
12.3 points per game, making the
Vikings +3
and
Under 46.5
the leading betting angles. Injuries to running backs Aaron Jones Sr. and Jahmyr Gibbs add uncertainty to both offenses.
The Lions average 30.7 points per game, but Minnesota's defense has recorded 21 sacks and seven interceptions through six games. Detroit also has injury concerns involving leading receiver Amon-Ra St. Brown and running back Jahmyr Gibbs, both of whom missed mid-week practices. These factors shape the NFL Picks for a divisional matchup where Minnesota's defensive strength could offset Detroit's scoring advantage.
Vikings vs Lions Game Preview
Minnesota enters at 6-0, allowing 12.3 points per game while recording 21 sacks and seven interceptions. Quarterback Kyler Murray has thrown for 812 yards, three touchdowns and two interceptions, while Detroit's Jared Goff has 1,788 passing yards, 14 touchdowns and zero interceptions. The Lions are 4-2 and average 30.7 points and 397.3 yards per game.
The Vikings have injury concerns along the offensive line, with Joe Huber and Jones missing early-week practices and Brian O'Neill limited. Detroit has listed Amon-Ra St. Brown and Gibbs among players who missed practice, while safety Kerby Joseph and cornerback Ennis Rakestraw were limited. Ford Field's fixed roof removes outdoor weather concerns, but both teams' offensive availability remains important.
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Vikings vs Lions Moneyline Pick
Take the Minnesota Vikings moneyline at +142 at DraftKings Sportsbook. Minnesota's 21 sacks, seven interceptions and +7 turnover differential give its defense a strong path to disrupting Goff, even against a Detroit offense averaging 30.7 points per game.
The +142 price offers a better return than laying -170 on Detroit, especially with the Vikings undefeated at 6-0. These NFL predictions favor Minnesota to win a close divisional game, with its defensive production supporting the underdog price.
Pick:
Vikings ML (+142 at
DraftKings Sportsbook).
Against the Spread Pick
Take the Minnesota Vikings +3 at -110 at DraftKings Sportsbook. The three-point spread is a key NFL number, so a Minnesota loss by exactly three points would result in a push. That protection matters in a matchup where Detroit's offensive output meets Minnesota's league-leading defensive production.
The Lions average 30.7 points per game, but Minnesota's defense has recorded 21 sacks and seven interceptions. Those takeaways and pressures can limit Detroit's scoring margin, while the Vikings' third-ranked average time of possession at 32:43 gives their offense a chance to keep Goff on the sideline. The statistical analysis of NFL teams supports taking the points rather than relying on a Minnesota outright win.
Pick:
Vikings +3 (-110 at DraftKings Sportsbook).
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Vikings vs Lions Game Total Pick
Take the Under 46.5 at DraftKings Sportsbook. Minnesota averages 20.8 points per game and ranks 29th with 281.7 yards per game, while its defense allows just 12.3 points per contest. Those numbers point to a lower-scoring game than Detroit's second-ranked offense might suggest.
Both defenses have recorded 21 sacks, creating pressure on opposing quarterbacks. Jones and Gibbs also carry knee and shoulder concerns, respectively, which could affect the running games if either player is limited. Ford Field is indoors, so wind and rain will not affect passing or kicking. These NFL Picks favor the Under because Minnesota's defensive pressure and limited offensive production create a clear path to fewer than 47 points.
Pick: Under 46.5 (odds not provided by DraftKings Sportsbook).
How to Watch Vikings vs Lions and Game Info
- Location:
Ford Field, Detroit, Michigan.
- Date:
Sunday, November 1, 2026
- Kickoff:
1:00 p.m. ET
- TV:
FOX
- Minnesota Vikings starting quarterback:
Kyler Murray (record as starter: TBD, 812 passing yards, 3 TD-2 INT).
- Detroit Lions starting quarterback:
Jared Goff (record as starter: TBD, 1,788 passing yards, 14 TD-0 INT).
- Weather forecast:
Indoors, no weather factor.
Final Takeaways
Minnesota's defensive pressure and +7 turnover differential make the Vikings the preferred moneyline value at +142 and the stronger spread play at +3. Detroit's offense averages 30.7 points per game, but Minnesota allows only 12.3, supporting the Under 46.5. These NFL predictions favor the Vikings to keep the game close and potentially secure an outright divisional win.
Check the latest NFL odds and
matchup coverage at betting.net
before placing your bets. All odds as of 1:40 am ET on October 29, 2026. Odds sourced from DraftKings Sportsbook.
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