Colts Vs Vikings: Betting Picks and Odds for NFL Week 7 Matchup
David Genge Published 22/10/2026
The Minnesota Vikings enter Week 7 unbeaten at 5-0 and host the Indianapolis Colts on Sunday, October 25. Minnesota is favored by 6.5 points, with DraftKings Sportsbook listing the Vikings' moneyline between -278 and -280 in the supplied odds. Indianapolis has a major problem to solve: its minus-eight turnover differential ranks last in the league, while Minnesota leads the NFL at plus-six.
These NFL Picks favor Minnesota to win, with the Under 41.5 points as the strongest total angle. The Vikings have recorded 17 sacks and six interceptions, both ranking among the league's top five. Indianapolis has managed only two interceptions on defense, leaving a clear gap in the statistical analysis of NFL teams.
Colts vs Vikings Game Preview
The Vikings are 5-0, while the Colts enter at 2-4. Indianapolis averages 24 points per game and 311.3 yards, compared with Minnesota's 21.8 points and 283 yards. Colts quarterback Daniel Jones has thrown for 1,290 yards, four touchdowns and six interceptions. Minnesota quarterback Kyler Murray has 662 passing yards, two touchdowns and two interceptions, with a 68.3% completion rate.
Indianapolis has 16 players on its initial injury report, including cornerback Sauce Gardner and tight end Tyler Warren, who missed Wednesday's practice. Minnesota had several key players return to full participation after its Week 6 bye, including left tackle Christian Darrisaw and tight end T.J. Hockenson. Justin Jefferson was limited with an ankle issue, while the game takes place indoors at U.S. Bank Stadium, removing weather as a factor.
Colts vs Vikings Moneyline Pick
Take the Minnesota Vikings moneyline at -280 at DraftKings Sportsbook. Minnesota's plus-six turnover differential compared with Indianapolis' minus-eight mark creates a 14-turnover gap between the teams. That difference, combined with Minnesota's 5-0 record and six interceptions on defense, supports the home side.
The price is steep, so bettors must weigh the return against the risk. A $280 wager at -280 would earn $100 in profit before the original stake is returned. Still, these NFL predictions favor Minnesota because Jones has six interceptions and the Colts have struggled to protect possession.
Pick: Minnesota Vikings ML (-280 at DraftKings Sportsbook).
Against the Spread Pick
Take the Minnesota Vikings -6.5 at DraftKings Sportsbook. The spread price was not provided, but the matchup statistics support Minnesota covering a margin of more than a touchdown. The Vikings have a plus-six turnover differential, while Indianapolis sits at minus-eight, giving the home team more chances to create short fields and extend leads.
The Colts' defense has recorded just two interceptions and 10 sacks, ranking 29th and 26th, respectively. Minnesota's 17 sacks can put pressure on Jones and disrupt Indianapolis drives. A 6.5-point spread sits between the key numbers of six and seven, so a seven-point Vikings win would cover, while a six-point win would not.
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Pick: Minnesota Vikings -6.5.
Colts vs Vikings Game Total Pick
Take the Under 41.5 points at DraftKings Sportsbook; the price for this total was not provided. Minnesota averages 21.8 points per game, and Indianapolis averages 24, giving a combined scoring average of 45.8. However, that figure does not account for Minnesota's strong turnover production or the Colts' difficulty protecting the football.
The Vikings rank fifth with 17 sacks and fifth with six interceptions, while Indianapolis has a minus-eight turnover differential. Those numbers support a game in which the Colts struggle to sustain drives and give Minnesota fewer reasons to play at a fast pace. The statistical analysis of NFL teams points to the Under as the preferred total, despite both offenses averaging more than 20 points per game.
Pick: Under 41.5.
How to Watch Colts vs Vikings and Game Info
- Location: U.S. Bank Stadium, Minneapolis, Minnesota.
- Date: Sunday, October 25, 2026
- Kickoff: 1:00 p.m. ET
- TV: CBS
- Indianapolis Colts starting quarterback: Daniel Jones (record as starter: TBD, 1,290 passing yards, 4 TD-6 INT).
- Minnesota Vikings starting quarterback: Kyler Murray (record as starter: TBD, 662 passing yards, 2 TD-2 INT).
- Weather forecast: Indoors, no weather factor.
Final Takeaways
Minnesota's 5-0 record and 14-turnover differential advantage make the Vikings the clear side in these NFL Picks. Back Minnesota on the moneyline at -280 and lay the 6.5 points, with the Under 41.5 as the total selection. These NFL predictions rely on the Vikings' defensive production and Indianapolis' turnover problems, which remain the biggest statistical gap in this matchup.
Check the latest odds and line movement for Colts vs Vikings at betting.net before placing your bets. All odds as of 1:05 a.m. ET on October 22, 2026. Odds sourced from DraftKings Sportsbook.