Texans at Colts Predictions, Odds and Betting Picks
Houston is a 2.5-point road favorite against Indianapolis, with the moneyline at -143 and the total at 43.5 at Caliente.mx. The Texans also bring a seven-sack defense through two games, while the Colts have allowed 514 yards per game, giving Houston a clear matchup edge.
The bigger concern for Indianapolis is its receiving corps. Alec Pierce is expected to miss several weeks with a heel injury, while Houston enters the game without Nico Collins because of a hamstring injury. These NFL Picks center on Houston's defensive pressure and Indianapolis' reduced big-play options.
Texans vs Colts Game Preview
Both teams are 0-2, but their offensive numbers differ. Houston averages 18.5 points and 377.5 yards per game, while C.J. Stroud has thrown for 627 yards with 2 touchdowns and no interceptions. Indianapolis averages 26.5 points and 290 yards per game, with Daniel Jones at 376 passing yards, 2 touchdowns and 2 interceptions.
Houston has also controlled the clock for an average of 32:44 per game, fourth in the NFL, and has seven sacks. Indianapolis has four sacks and has allowed 514 yards per game, creating a major defensive contrast entering this AFC South matchup. Those numbers are central to the NFL predictions for Sunday. Houston lost Henry To'oTo'o to IR, while Pierce is dealing with a heel injury. The Colts signed Darius Slayton, reuniting him with Jones.
Texans vs Colts Moneyline Pick
Take the Texans moneyline at -143 at Caliente.mx. Stroud has 627 passing yards with 0 interceptions through two games, while Houston's defense has already recorded seven sacks. Indianapolis has allowed 514 yards per game, making the Colts' defense a difficult matchup against a Houston offense producing 377.5 yards per game.
The price is reasonable for a short road favorite because Houston has a stronger pressure profile and a cleaner quarterback turnover record. Indianapolis has also lost Pierce, who had 1,000 receiving yards in 2025, further reducing its deep-threat options. This is the clearest side among these NFL Picks.
Pick: Texans ML (-143 at Caliente.mx).
Against the Spread Pick
Take the Texans -2.5 at -115 at Caliente.mx. The number sits below the key number of 3, which gives Houston some protection compared with laying a full field goal, and the Texans' 377.5 yards per game give them enough offensive volume to create separation.
Houston's seven sacks also matter for the margin. Indianapolis has produced only 290 yards per game, and its offense loses Pierce's vertical threat, while the Texans have held a 32:44 average time of possession. If Houston wins the possession battle again, a field-goal margin is within reach without requiring a blowout.
For bettors comparing Expert betting tips for NFL games, the key is the margin rather than simply picking the winner. Houston -2.5 gives the favorite room to win by three or more, while Indianapolis' 0-2 record and 514 yards allowed per game point to another difficult defensive assignment.
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
+9
- 20+ sports available for wagering
- Pre-match and in-play betting
- Unique features like live streaming and boosted odds
Bet $10 Get $365 in Bonus Bets Win or Lose
Find out more on bet365's website
- Over 20 sports
- Extensive betting markets
- Live betting feature
New Users – Get $250 in Bonus Bets when you wager $5 for 5 days
+6
- Deep market coverage across major U.S. sports and leagues
- Same Game Parlay builder is fast and easy to use
- Live betting interface updates quickly with real-time odds
Texans vs Colts Game Total Pick
Take the Under 43.5 at -110 at Caliente.mx. Houston has scored only 18.5 points per game through two weeks, and the Texans have relied on long possessions, averaging 32:44 in time of possession. That approach can shorten the game and reduce the number of possessions available to both offenses.
Indianapolis averages 26.5 points, but it has lost Pierce after his heel injury and now faces a Houston defense with seven sacks. Stroud has protected the ball with 0 interceptions, yet Houston's overall scoring output remains modest, making 43.5 a high enough number for an Under position.
How to Watch Texans vs Colts and Game Info
- Location: Lucas Oil Stadium, Indianapolis, IN
- Date: Sunday, September 27, 2026
- Kickoff: 1:00 p.m. ET
- TV: CBS
- Texans starting quarterback: C.J. Stroud (TBD, 627 yards, 2-0).
- Colts starting quarterback: Daniel Jones (TBD, 376 yards, 2-2).
- Weather forecast: Indoors, no weather factor.
Final Takeaways
Houston's seven sacks, 377.5 yards per game and Indianapolis' 514 yards allowed per game create the central betting angle. The Texans are the moneyline pick at -143, while Houston -2.5 is the spread pick at -115. The Under 43.5 is the total pick at -110, with Houston's 18.5 points per game and 32:44 time of possession supporting the lower-scoring side. These NFL predictions also reflect the loss of Pierce and Houston's ability to pressure the quarterback.
All odds as of 1:53 a.m. ET on September 23, 2026. Odds sourced from Caliente.mx. Check the latest odds and line movement for Texans vs. Colts at betting.net before placing your bets.