Steelers at Patriots Predictions, Odds and Betting Picks
The Pittsburgh Steelers are the betting side to watch at +200 on the moneyline as they visit the New England Patriots on Sunday. New England is favored by 4.5 points at FanDuel Sportsbook, but Drake Maye threw 3 interceptions in a 13-10 Week 1 loss, while Pittsburgh recorded 4 sacks and 2 interceptions in its 20-13 win over Atlanta.
The 42.5-point total also sets up for a defensive game. Pittsburgh allowed 4.2 yards per play against Atlanta, while New England scored only 10 points against Seattle. Those numbers give bettors a clear starting point for this week's NFL Picks.
Steelers vs Patriots Game Preview
The Steelers enter Week 2 at 1-0 after beating Atlanta 20-13, with Aaron Rodgers completing 24 of 40 passes for 221 yards, 1 touchdown and 0 interceptions. The Patriots are 0-1 after their 13-10 loss to Seattle, with Maye completing 23 of 33 passes for 178 yards, 1 touchdown and 3 interceptions. Pittsburgh also produced 20 points and 264 total yards in Week 1, compared with 10 points and 277 yards for New England.
New England will be without A.J. Brown, while Christian Gonzalez and Keion White are questionable. Pittsburgh has 3 defensive starters out, with Joey Porter Jr. also dealing with a back issue. Rain, 92% humidity and 7 to 8 mph winds are expected at kickoff.
Steelers vs Patriots Moneyline Pick
Take the Steelers moneyline at +200. Pittsburgh has the stronger turnover profile after forcing 2 interceptions and recording 4 sacks in Week 1, while Maye gave the ball away 3 times against Seattle. Rodgers also finished his opener with 221 passing yards and no interceptions, giving Pittsburgh a safer turnover profile at quarterback.
The +200 price implies a 33.3% break-even rate. Pittsburgh can stay close, especially with New England scoring 10 points in Week 1 and A.J. Brown on IR. These NFL predictions favor the Steelers to keep it within one score.
Pick: Steelers ML (+200 at FanDuel Sportsbook).
Against the Spread Pick
Take the Steelers +4.5 at -110. Pittsburgh won by 7 points against Atlanta despite producing only 20 points, while New England lost by 3 points in Seattle after committing 3 turnovers. A 4.5-point cushion also protects the Steelers against a close game decided by a field goal.
The spread is important because the Steelers do not need to win outright to cover. Pittsburgh's 4 sacks and 2 interceptions from Week 1 give its defense a path to limit New England's scoring margin, while the Patriots managed only 10 points and 277 total yards in their opener. For bettors looking for NFL Picks based on margin rather than just the winner, +4.5 is the key number.
Pick: Steelers +4.5 (-110 at FanDuel Sportsbook).
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Steelers vs Patriots Game Total Pick
Take the Under 42.5 at -110. Both teams stayed below this number in Week 1, with Pittsburgh and Atlanta combining for 33 points and New England and Seattle combining for 23 points. The Steelers also finished Week 1 with 264 yards, while the Patriots had 277 yards, keeping both offenses below 300 total yards.
The weather adds another factor, with rain showers, 92% humidity and winds of 7 to 8 mph forecast around kickoff. Maye's 3 interceptions and Pittsburgh's 4 sacks also point toward a game where turnovers and pressure can slow scoring drives. That combination makes the Under central to the Expert betting tips for NFL games in this matchup.
Pick: Under 42.5 (-110 at FanDuel Sportsbook).
How to Watch Steelers vs Patriots and Game Info
- Location: Gillette Stadium, Foxborough, MA
- Date: Sunday, September 20, 2026
- Kickoff: 1:00 p.m. ET
- TV: CBS
- Steelers starting quarterback: Aaron Rodgers (1-0, 221 yards, 1-0).
- Patriots starting quarterback: Drake Maye (0-1, 178 yards, 1-3).
- Weather forecast: 61°F to 66°F, rain showers, wind out of the southeast at 7 to 8 mph.
Final Takeaways
Pittsburgh's defense has the better turnover numbers after producing 4 sacks and 2 interceptions in Week 1, while New England enters with a 3-turnover performance and only 10 points scored. The NFL Picks are Steelers ML +200, Steelers +4.5 and Under 42.5. The NFL predictions lean toward a tight game because Pittsburgh can create pressure while the Patriots have to replace Brown in the passing game. These Expert betting tips for NFL games center on Pittsburgh's defense, the +4.5 spread and a low-scoring total.
All odds as of 5:20 p.m. ET on September 14, 2026. Odds sourced from FanDuel Sportsbook. Check the latest odds and line movement for Steelers vs Patriots at betting.net before placing your bets.