Seahawks at Commanders Predictions, Odds and Betting Picks
Seattle is the clear betting side against Washington in Week 3. The Seahawks are 2-0, have forced 4 interceptions through two games, and enter with a 7-point road spread at bet365. Washington will start Marcus Mariota with Jayden Daniels ruled out because of a left elbow injury.
The market also lists Seattle at -310 on the moneyline and the total at 40.5 at bet365. Washington has six players listed as nonparticipants Thursday, including Daniels, Sam Cosmi, Nick Cross, Frankie Luvu and Chigoziem Okonkwo. These NFL Picks start with Seattle's defense and Washington's reduced offensive options.
Seahawks vs Commanders Game Preview
Seattle is 2-0 and has scored 22 points per game while averaging 333 yards. Drew Lock has completed 35 of 48 passes for 422 yards, 4 touchdowns and no interceptions, giving him a 127.26 passer rating. Washington is 0-2 and averages 21 points and 342 yards per game, while Mariota enters with 111 passing yards and one touchdown after replacing Daniels against Dallas.
Sam Darnold was a full participant Thursday, but Lock remains the stated starter in the supplied matchup data. Washington has Daniels, Cosmi, Cross, Luvu and Okonkwo unavailable for practice. The game is at Northwest Stadium with 75°F partly sunny conditions and minimal wind, while Seattle arrives at 2-0 and Washington opens its home schedule at 0-2.
For bettors comparing best NFL betting sites, Seattle has a +3 turnover differential and 4 interceptions, while Washington has 0 interceptions and a -1 turnover differential. That gap is central to the Trends in NFL team performance for this matchup.
Seahawks vs Commanders Moneyline Pick
Take the Seattle Seahawks moneyline at -310 at bet365. Seattle has 4 interceptions and a +3 turnover differential, while Washington has no interceptions through two games. Lock has posted 422 yards and 4 touchdowns without an interception.
The -310 price is expensive, but Daniels is out and Mariota is making his first start of the season. Mariota completed 11 of 16 passes for 111 yards and a touchdown last week, while Seattle's defense has 5 sacks and 13 quarterback hits. That makes Seattle the direct choice for NFL predictions on the moneyline.
Pick: Seattle Seahawks ML (-310 at bet365).
Against the Spread Pick
Take Seattle Seahawks -7 at -110 at bet365. The key number is 7, so bettors are laying a full touchdown and need Seattle to win by at least 8 for a standard cover. Seattle's defense has 5 sacks, 14 tackles for loss and 4 interceptions.
The spread case is about game control rather than simply picking the winner. Washington has 5 sacks but no interceptions, while Seattle has a +3 turnover differential. Extra possessions give Seattle more chances to separate late, which matters when evaluating NFL Picks against a full touchdown.
Pick: Seattle Seahawks -7 (-110 at bet365).
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Seahawks vs Commanders Game Total Pick
Take the Under 40.5 at -115 at bet365. The total sits below the combined season scoring average of 43 points per game, based on Seattle's 22 and Washington's 21. Seattle's 4 interceptions and 5 sacks also point toward pressure on Washington's offense.
Washington has 342 yards per game but just 21 points, while Seattle has 333 yards and 22 points. Both teams are gaining yards without producing a high-scoring profile. With a 75°F partly sunny forecast and minimal wind, the Under call rests on offensive efficiency and quarterback circumstances. That fits the Statistical analysis of NFL teams better than a weather-based total.
Pick: Under 40.5 (-115 at bet365).
How to Watch Seahawks vs Commanders and Game Info
- Location: Northwest Stadium, Landover, MD.
- Date: Sunday, September 27, 2026
- Kickoff: 1:00 p.m. ET
- TV: FOX
- Seattle Seahawks starting quarterback: Drew Lock (TBD, 422 yards, 4-0).
- Washington Commanders starting quarterback: Marcus Mariota (0-0, 111 yards, 1-0).
- Weather forecast: 75°F, partly sunny.
Final Takeaways
Seattle's defensive turnover edge and Washington's quarterback change shape all three NFL predictions here. The moneyline is Seattle -310, the spread is Seattle -7, and the total is Under 40.5 at bet365. The Trends in NFL team performance show Seattle with a +3 turnover differential and 4 interceptions, compared with 0 interceptions and -1 for Washington. Bettors looking for NFL Picks should treat 7 as the key spread number and 40.5 as the scoring threshold.
All odds as of 7:23 PM ET on September 24, 2026. Odds sourced from bet365. Check the latest odds and line movement for Seahawks vs Commanders at betting.net before placing your bets.