Rams at Eagles Predictions, Odds and Betting Picks
David Genge Published 02/10/2026
The Los Angeles Rams are 3-point road favorites over the Philadelphia Eagles in a Week 4 matchup where injuries have a major impact on the betting board. The Eagles enter Sunday without DeVonta Smith, Dallas Goedert, Marquise Brown and Fred Johnson, while the Rams are expected to get Puka Nacua back after his return to practice.
The Rams also bring the league's top offense by yardage at 417.7 yards per game. Philadelphia is averaging just 18.3 points and 302.3 yards per game, making the matchup between Matthew Stafford's passing attack and an injury-hit Eagles offense the central factor for these NFL Picks.
Rams vs Eagles Game Preview
The Rams are 1-2 after losses to the 49ers and Broncos, while Philadelphia is 2-1 after a 27-7 loss to Chicago. Stafford has completed 60.4% of his passes for 872 yards, 6 touchdowns and 4 interceptions, while Jalen Hurts has completed 64.4% for 620 yards, 5 touchdowns and 3 interceptions. Los Angeles is averaging 417.7 yards per game compared with 302.3 for Philadelphia.
The injury reports create a clear difference in available offensive weapons. Nacua returned to practice for Los Angeles, while Philadelphia has Smith, Goedert, Brown and Johnson listed out, and Zack Baun has also missed practice. The Rams also face a road trip after playing in Denver last Sunday, while Philadelphia returns home for a 1 p.m. ET kickoff.
Rams vs Eagles Moneyline Pick
Take the Los Angeles Rams moneyline at -162 at DraftKings Sportsbook. Stafford has thrown for 872 yards and 6 touchdowns through three games, while the Rams are producing 417.7 yards per game, the best mark in the league.
Philadelphia's offensive injuries make the price more reasonable. Smith has 235 receiving yards, Goedert has 81 yards and 2 touchdowns, and Johnson is out, leaving Hurts with fewer established options. These NFL predictions lean toward Los Angeles because its passing game has more available production.
Pick: Rams ML (-162 at DraftKings Sportsbook).
Against the Spread Pick
Take the Los Angeles Rams -3 at -108 at DraftKings Sportsbook. The number sits directly on the key field-goal margin, so a Rams win by exactly 3 would result in a push at a standard spread.
The margin case comes from the gap in recent offensive production. Los Angeles has gained 417.7 yards per game and has scored 61 points through three games, while Philadelphia has managed 55 points and 302.3 yards per game. The Eagles are also 0-3 against the spread entering Week 4, while the Rams are 1-2 ATS, giving this statistical analysis of NFL teams a clear focus on the difference in offensive output.
The Rams do not need a blowout to cash this ticket. A 27-23 type of result clears the number, while Philadelphia's depleted receiving group increases the chance that the Eagles struggle to keep pace late.
Pick: Rams -3 (-108 at DraftKings Sportsbook).
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Rams vs Eagles Game Total Pick
Take the Under 43.5 at -120 at DraftKings Sportsbook. The total opened at 47.5 before dropping to 43.5, a significant move toward a lower-scoring game.
Philadelphia averages 18.3 points and 302.3 yards per game, with key pass catchers dealing with injuries. Rain and 7 to 8 mph winds could also favor the run. The Rams average 20.3 points despite 417.7 yards per game. With both teams coming off losses, the NFL Picks and NFL predictions point to a game staying below 44 points.
Pick: Under 43.5 (-120 at DraftKings Sportsbook).
How to Watch Rams vs Eagles and Game Info
- Location: Lincoln Financial Field, Philadelphia, PA.
- Date: Sunday, October 4, 2026
- Kickoff: 1:00 p.m. ET
- TV: FOX
- Los Angeles Rams starting quarterback: Matthew Stafford (TBD, 872 yards, 6-4).
- Philadelphia Eagles starting quarterback: Jalen Hurts (TBD, 620 yards, 5-3).
- Weather forecast: 64°F, rainy, wind out of the east at 7 to 8 mph.
Final Takeaways
The Rams have the stronger offensive numbers, with 417.7 yards per game compared with Philadelphia's 302.3. The Eagles' injuries at wide receiver, tight end and tackle also make it harder for Hurts to match Stafford's production. The NFL predictions are Rams ML, Rams -3 and Under 43.5. These NFL Picks are based on the Rams' yardage edge, Philadelphia's offensive absences and the drop from a 47.5-point opener to 43.5.
All odds as of 8:00 a.m. ET on October 2, 2026. Odds sourced from DraftKings Sportsbook. Check the latest odds and line movement for Los Angeles Rams vs Philadelphia Eagles at betting.net before placing your bets.