Raiders Vs 49ers: Betting Picks and Odds for NFL Week 9 Matchup
Jesse M. Cox Published 06/11/2026
The San Francisco 49ers enter Sunday's matchup as 9.5-point favorites against the Las Vegas Raiders. DraftKings Sportsbook lists San Francisco at -485 on the moneyline, while Las Vegas is priced at +370. The Raiders' 6-2 record against the spread gives bettors a reason to consider the road underdog despite San Francisco's strong offensive numbers.
San Francisco ranks first in offensive success rate and averages 28.1 points per game. However, Las Vegas averages 27.6 points and has a +5 turnover differential, giving the Raiders a chance to stay competitive. These NFL predictions focus on San Francisco's winning chances, Las Vegas covering the spread, and the potential for a high-scoring game.
Raiders vs 49ers Game Preview
The Raiders enter Week 10 at 4-4, while the 49ers are 6-1. Kirk Cousins has 2,124 yards, 19 touchdowns, and five interceptions, while Brock Purdy has 1,748 yards, 15 touchdowns, and four interceptions. San Francisco also leads in total offense, averaging 371.4 yards per game against Las Vegas' 342.4.
Both teams have injury concerns. Thomas Booker missed practice with an ankle injury, while Darien Porter and Dont'e Thornton were limited. Christian McCaffrey and Deebo Samuel returned to limited practice, but Mike Evans and Christian Kirk were absent, and Nick Bosa remained limited. These factors shape the NFL predictions, while clear skies and 3 mph winds favor both offenses.
Raiders vs 49ers Moneyline Pick
Take the 49ers. San Francisco's defense is the engine: second in yards per play allowed, giving up just 3.48 yards per rush and 10.01 yards per catch, all second-best in the league per the cited data. That efficiency limits the Raiders' explosiveness; although Las Vegas is eighth in points per play, they still allow 28.8 points per game and look exposed in step-up spots.
On offense, Purdy's 110.1 rating and Christian McCaffrey's 640 scrimmage yards (389 rush, 251 receiving) provide a steady baseline, while the Raiders' defense has leaked 28.8 per game. The price is rich, but the 49ers at home with a rested roster and a Buckner bump is the right side.
Pick: 49ers ML (-535 at DraftKings).
Against the Spread Pick
Lay it with the 49ers -10. San Francisco has the tools to stretch the margin late because their defense squeezes possessions. Opponents average just 19.86 points per game against them, and they've allowed only 13 touchdowns all season, seventh-fewest. That limits backdoor scripts.
The key number moved from -8.5 to -10, via -9. If -9.5 isn't available, -10 remains playable since the matchup favors a two-score outcome. The Raiders average 26.0 points but have been uneven (0.492 last game, 0.378 over three), against a defense that ranks second per play.
Pick: 49ers -10 (-105 at DraftKings).
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Raiders vs 49ers Game Total Pick
Play the Under 52.5. San Francisco's defense is built to kill explosives and force long drives: second in yards per play allowed and only 223.9 passing yards surrendered per game. That shaves variance from a Raiders unit that ranks 11th in offensive touchdowns per game at 2.8 and thrives on chunk gains to tight ends Brock Bowers and Michael Mayer.
The 49ers score 29.4 offensive points per game and sit second in points per play, but their tempo is measured, and the matchup tilts to a controlled script with McCaffrey touches and a defense that has allowed just 5 rushes of 10+ yards on 174 carries, best in the NFL. With the spread at -10, endgame pace also favors clock bleed rather than a shootout. NFL Picks
Pick: Under 52.5 (-110 at DraftKings).
How to Watch Raiders vs 49ers and Game Info
- Location: Levi's Stadium in Santa Clara, California, where the Raiders visit the 49ers.
- Date: Sunday, November 8, 2026
- Kickoff: 4:25 p.m. ET
- TV: FOX
- Raiders starting quarterback: Kirk Cousins (4-4, 2,124 yards, 19 touchdowns, 5 interceptions).
- 49ers starting quarterback: Brock Purdy (6-1, 1,748 yards, 15 touchdowns, 4 interceptions).
- Weather forecast: 72°F, clear skies, wind out of the northwest at 3 mph.
Final Takeaways
This is a 49ers defense vs Raiders offense matchup. Pick: 49ers ML, -10, total under 52.5. Check our best NFL betting sites.
If you're building out broader NFL predictions or even tinkering with NFL playoffs predictions, remember to price in per-play efficiency as much as raw point totals. It will sharpen your NFL Picks week to week. For more tools, check our guides to the best betting sites and current promo options at our betting.net promo codes page.
All odds as of 1:27 a.m. ET on November 6, 2026. Odds sourced from DraftKings Sportsbook. Check the latest odds and line movement for Raiders vs 49ers at betting.net before placing your bets.