New York Giants at Los Angeles Rams Predictions, Odds and Betting Picks
The Los Angeles Rams are 7-point home favorites against the New York Giants, with the game total at 47.5 points. BetMGM lists Los Angeles at -300 on the moneyline and New York at +250, while Puka Nacua is questionable with a hip injury. That injury matters because Nacua caught 5 passes for 74 yards in the Rams' opener.
New York enters this Monday night game after a 28-20 win over Dallas, while Los Angeles is trying to rebound from a 27-7 loss to San Francisco. The Giants' secondary is also dealing with injuries, including Paulson Adebo on injured reserve and Deonte Banks questionable with a calf injury.
Giants vs Rams Game Preview
Jaxson Dart completed 79.3% of his passes for 230 yards and 3 touchdowns, while Cam Skattebo ran for 81 yards and a touchdown on 18 carries. The Rams managed only 290 yards and 7 points in their opener, with Matthew Stafford throwing for 155 yards, 0 touchdowns and 1 interception.
New York held the ball for 36:40 in Week 1, compared with 26:10 for Los Angeles. The Giants also have Banks and Micah McFadden listed as questionable, while the Rams have safety Kamren Kinchens ruled out and Nacua questionable. Aaron Donald is expected to return for Los Angeles after missing Week 1, while SoFi Stadium has a fixed roof and removes weather from the betting equation.
Giants vs Rams Moneyline Pick
Take the Rams moneyline at -300. Los Angeles has the home-field edge after opening the season in Australia, and Stafford has the veteran experience to settle the offense. New York's depleted cornerback group gives the Rams a clear matchup to attack.
The price is expensive, but the Rams only need to win. New York's 28 points and 394 yards against Dallas show that Dart can move the offense, but Los Angeles has the home setting and quarterback experience needed to control the game. These are the core NFL Picks for this market.
Pick: Rams ML (-300 at BetMGM).
Against the Spread Pick
Take Giants +7 (-118 at BetMGM). The full touchdown is a key NFL number, and New York already showed the ability to protect a lead and manage long drives with 36:40 of possession against Dallas.
The Giants also gained 165 rushing yards in Week 1, giving them another way to shorten the game and stay within one score. Los Angeles scored only 7 points in Australia, so asking the Rams to win by more than a touchdown is a bigger margin requirement than the moneyline. That makes New York +7 the preferred spread side in these NFL predictions.
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Giants vs Rams Game Total Pick
Take Under 47.5 (-108 at BetMGM). Los Angeles scored 7 points and gained 290 yards in Week 1, while Stafford had no touchdown passes and one interception. The Rams also recorded 0 sacks and held the ball for only 26:10.
Nacua's questionable status adds another variable to a Los Angeles passing attack that produced just 155 Stafford passing yards in the opener. New York can also shorten the game with Skattebo after his 81-yard, 4.5-yard-per-carry performance. With the game indoors, the total comes down to offensive efficiency rather than weather, making the Under one of the Expert betting tips for NFL games for this matchup.
Pick: Under 47.5 (-108 at BetMGM).
How to Watch New York Giants vs Los Angeles Rams and Game Info
- Location: SoFi Stadium, Inglewood, CA
- Date: Monday, September 21, 2026
- Kickoff: 8:15 p.m. ET
- TV: ABC, ESPN
- New York Giants starting quarterback: Jaxson Dart (1-0, 230 yards, 3-0).
- Los Angeles Rams starting quarterback: Matthew Stafford (0-1, 155 yards, 0-1).
- Weather forecast: Indoors, no weather factor.
Final Takeaways
The Rams have the home-field edge and quarterback experience to win, but the Giants have enough offensive production to stay within a touchdown. The picks are Rams ML at -300, Giants +7 at -118, and Under 47.5 at -108. Bettors following NFL Picks, NFL predictions, and Expert betting tips for NFL games should check Nacua's status before placing a wager.
Check the latest odds and line movement for New York Giants vs Los Angeles Rams at betting.net before placing your bets. All odds as of 12:48 a.m. ET on September 21, 2026. Odds sourced from BetMGM.