Eagles at Jaguars Predictions, Odds and Betting Picks
Jesse M. Cox Published 06/10/2026
The Jacksonville Jaguars are the clear betting side at -4.5 against the Philadelphia Eagles in Sunday's London matchup. DraftKings Sportsbook lists Jacksonville at -218 on the moneyline and the total at 43.5, while Philadelphia enters with major injuries affecting its offense.
Jacksonville also has the stronger quarterback numbers. Trevor Lawrence has 843 passing yards, eight touchdowns and two interceptions with a 111.18 passer rating, while Jalen Hurts has 713 yards, seven touchdowns and three interceptions with an 87.35 rating. That gap is central to these NFL Picks.
Eagles vs Jaguars Game Preview
Philadelphia is 2-2 and has lost two straight, while Jacksonville is 3-1 after wins over Cleveland, New England and Cincinnati. The Eagles are 0-4 against the spread, and their offense ranks 26th in scoring at 18.8 points per game and 29th in total yards at 269.8 per game. Jacksonville is averaging 26 points and 316.5 yards per game, giving the Jaguars the stronger statistical profile entering London.
The injury list makes that gap harder to close. Saquon Barkley has 182 rushing yards but left Week 4 with a hamstring injury, while DeVonta Smith and Dallas Goedert are also dealing with injuries. Jacksonville has 10 sacks and a +6 turnover differential, compared with four sacks and -3 for Philadelphia, key points in the Statistical analysis of NFL teams.
Eagles vs Jaguars Moneyline Pick
Take the Jacksonville Jaguars moneyline at -218. Lawrence has completed 69.2% of his passes for 843 yards and eight touchdowns, while Jacksonville has six interceptions and a +6 turnover differential. Philadelphia has only two interceptions and a -3 turnover margin, giving Jacksonville the clear edge in a game where turnovers can quickly decide the result.
The -218 price is steep, but Jacksonville is 9-2 against the spread when favored under Liam Coen since the start of 2025. The Jaguars also held Cincinnati to 17 points in Week 4, while Philadelphia has scored only 27 points across its last two games. These NFL predictions favor Jacksonville because the matchup supports the price.
Pick: Jaguars ML (-218 at DraftKings Sportsbook).
Against the Spread Pick
Take Jacksonville Jaguars -4.5 at -110. The number sits 1.5 points above the key number of 3, but Jacksonville has covered in all three of its wins this season while Philadelphia is 0-4 ATS. The Jaguars have also posted enough winning margins to clear the number in each of those three victories.
Philadelphia's backdoor-cover risk is limited by an offense averaging only 18.8 points and 269.8 yards per game. Jacksonville has 10 sacks and six interceptions compared with four sacks and two interceptions for Philadelphia, giving the Jaguars more ways to create separation without needing a perfect offensive game.
Pick: Jaguars -4.5 (-110 at DraftKings Sportsbook).
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Eagles vs Jaguars Game Total Pick
Take Under 43.5 at -120. Jacksonville's games have gone Under in three of four contests, while Philadelphia has gone Over in three of four, but the matchup points toward the Eagles struggling to sustain drives. Philadelphia averages 18.8 points and 269.8 yards per game, while Jacksonville has already produced 10 sacks and six interceptions.
Weather also favors a lower-scoring game. With temperatures near 61°F and west winds of 9 to 11 mph, the conditions could limit scoring. The Statistical analysis of NFL teams also points to a tighter game than the 43.5 total suggests.
Pick: Under 43.5 (-120 at DraftKings Sportsbook).
How to Watch Eagles vs Jaguars and Game Info
- Location: Tottenham Hotspur Stadium, London, England.
- Date: Sunday, October 11, 2026
- Kickoff: 9:30 a.m. ET
- TV: NFL Network
- Philadelphia Eagles starting quarterback: Jalen Hurts (TBD, 713 yards, 7-3).
- Jacksonville Jaguars starting quarterback: Trevor Lawrence (TBD, 843 yards, 8-2).
- Weather forecast: 61°F, partly sunny to mostly cloudy, wind out of the west at 9 to 11 mph.
Final Takeaways
Jacksonville has the better quarterback numbers, stronger turnover margin and healthier offense, while Philadelphia enters London averaging just 18.8 points and 269.8 yards per game. The NFL Picks are Jaguars ML, Jaguars -4.5 and Under 43.5. The NFL predictions lean toward Jacksonville because the Eagles' injuries reduce their margin for error against a defense with 10 sacks and six interceptions. This Statistical analysis of NFL teams makes the Jaguars the clear side and the Under the preferred total.
All odds as of 4:15 a.m. ET on October 6, 2026. Odds sourced from DraftKings Sportsbook. Check the latest odds and line movement for Philadelphia Eagles vs Jacksonville Jaguars at betting.net before placing your bets.