Cardinals Vs Seahawks: Betting Picks and Odds for NFL Week 9 Matchup
Jesse M. Cox Published 06/11/2026
The Seattle Seahawks are 8.5-point favorites against the Arizona Cardinals in their Week 9 matchup at Lumen Field on Sunday, November 8. Seattle's quarterback situation is the biggest factor, as Sam Darnold is ruled out with quadriceps and rib injuries, leaving Drew Lock to start despite dealing with a right elbow issue.
DraftKings lists Seattle at -455 on the moneyline, while Arizona is priced at +350. The total is 40.5 points, making the quarterback changes and expected rain important factors in these NFL predictions. Seattle has the stronger turnover numbers, but Arizona's ability to control possession gives the Cardinals a chance to keep the game competitive.
Cardinals vs Seahawks Game Preview
Arizona enters Week 9 after a 14-point comeback win over Dallas, with Gardner Minshew II named the permanent starter. The Cardinals average 21.9 points and 333 yards per game, while Seattle averages 23.1 points and 331.9 yards. Drew Lock replaces Sam Darnold, who has thrown for 1,478 yards, 10 touchdowns, and nine interceptions.
Darnold is out, while Charles Cross and Leonard Williams have missed practice. Lock is also dealing with a right elbow injury. Arizona has Bam Knight in concussion protocol and Jeremiyah Love nursing an ankle injury. Seattle expects rain, temperatures of 52°F to 56°F, and south-southeast winds at 7 mph.
Cardinals vs Seahawks Moneyline Pick
The Arizona Cardinals moneyline at +350 is the value play at DraftKings. Seattle has the better overall turnover numbers, with eight interceptions compared to Arizona's three, but the Seahawks are starting Lock after losing Darnold. Lock's right elbow injury adds another concern, especially against an Arizona defense that has recorded 19 sacks.
Arizona also has a possession advantage, averaging 32:24 per game compared to Seattle's 30:54. That difference gives Minshew's offense more opportunities to control the clock and limit Seattle's possessions. At +350, the Cardinals offer a strong underdog price in these NFL Picks, especially if Lock struggles to establish the passing game.
Pick: Arizona Cardinals ML (+350 at DraftKings).
Against the Spread Pick
Take the Arizona Cardinals +8.5 at -115 at DraftKings. Arizona's offense averages 333 yards per game and ranks fourth in time of possession, giving Minshew a chance to keep drives alive and limit Seattle's scoring opportunities. The Cardinals also scored 33 points against Dallas in Week 8, showing they can produce enough offense to stay within a large number.
The 8.5-point spread gives Arizona more than a touchdown of room. Seattle's 18 defensive sacks are only one more than Arizona's 19, so the Seahawks do not have a major advantage in overall sack production. With Lock dealing with an elbow injury and Seattle potentially missing Cross and Shaheed, Arizona has a reasonable path to covering even if the home team wins. These Trends in NFL team performance support taking the points rather than laying a large number with Seattle.
Pick: Arizona Cardinals +8.5 (-115 at DraftKings).
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Cardinals vs Seahawks Game Total Pick
Take the Under 40.5 points at DraftKings. Both teams are dealing with quarterback changes, and neither offense has its usual starter available. Lock is replacing Darnold for Seattle, while Minshew is making his first start after throwing for 188 yards and three touchdowns in his Week 8 relief appearance.
Seattle averages 23.1 points per game, while Arizona averages 21.9. However, the offensive injuries and expected rain showers create a tougher scoring environment than those season averages suggest. Seattle's missing offensive linemen and Arizona's running back concerns also add uncertainty to both offenses. This Statistical analysis of NFL teams supports an Under selection, particularly with both quarterbacks facing different challenges entering Week 9.
Pick: Under 40.5 (-110 at DraftKings).
How to Watch Cardinals vs Seahawks and Game Info
- Location: Lumen Field, Seattle, WA.
- Date: Sunday, November 8, 2026
- Kickoff: 4:25 p.m. ET
- TV: FOX
- Arizona Cardinals starting quarterback: Gardner Minshew II (17/23, 188 yards, 3-0).
- Seattle Seahawks starting quarterback: Drew Lock (35/48, 422 yards, 4-0).
- Weather forecast: 52°F to 56°F, rain showers, wind from the south-southeast at 7 mph.
Final Takeaways
Seattle has the stronger turnover numbers, but Darnold's absence and Lock's elbow injury make the 8.5-point spread difficult to trust. Arizona is my moneyline underdog at +350 and the preferred spread pick at +8.5, while the quarterback changes and offensive concerns support the Under 40.5. These NFL predictions favor Arizona's ability to keep the game close, even if Seattle gets the home victory. Bettors comparing NFL Picks should weigh the quarterback situation heavily before placing their wagers.
Odds attribution: All odds as of 1:56 a.m. ET on November 6, 2026. Odds sourced from DraftKings. Check the latest odds and line movement for Cardinals vs Seahawks at betting.net before placing your bets.