Cardinals at Chargers Predictions, Odds and Betting Picks
The Los Angeles Chargers are 9.5-point favorites over the Arizona Cardinals, with ESPN listing a -559 moneyline and a 47.5-point total. The biggest betting factor is the matchup between Justin Herbert and a Cardinals offense dealing with a potential starting right guard absence.
The game is indoors at SoFi Stadium, removing wind and rain from the equation. That makes the 47.5-point total more dependent on quarterback efficiency, scoring chances and how well Arizona handles Los Angeles' defensive pressure.
Cardinals vs Chargers Game Preview
Arizona enters Week 1 with Jacoby Brissett at quarterback, while Los Angeles turns to Justin Herbert. The available data does not provide either team's last-five record or recent scoring margin, but the market has made the Chargers a 9.5-point favorite and models give them roughly a 74% to 83% chance to win.
The Cardinals have Isaiah Adams listed as a non-participant with a knee issue, while rookie Chase Bisontis is out with an MCL injury. Los Angeles has Keaton Mitchell and Tuli Tuipulotu listed as limited, while Khalil Mack was a full participant. With both teams opening the season and playing inside a controlled 65°F environment, there is no weather-based rest or travel adjustment to change the matchup.
For bettors building NFL Picks, the main question is whether Los Angeles can turn its clear talent edge into a margin large enough to justify the spread. Comparing prices across the best NFL betting sites is important when a number sits as high as -9.5.
Cardinals vs Chargers Moneyline Pick
Take the Los Angeles Chargers moneyline at -559. Herbert gives Los Angeles the stronger quarterback setup, while Arizona enters the game with Adams potentially missing at right guard and Bisontis already ruled out long term.
The price is expensive, but the Chargers' estimated 74% to 83% win probability supports them as the expected winner. The Cardinals at +420 need a major upset to cash, while the Chargers need only to win outright.
Pick: Los Angeles Chargers ML (-559 at ESPN).
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Against the Spread Pick
Take the Arizona Cardinals +9.5. The spread gives Arizona nearly double the margin of a one-score game, and that matters when the most common projected scores have Los Angeles winning by roughly 10 to 13 points.
The Chargers are projected around 27 to 30 points, while Arizona commonly lands between 10 and 17 in simulations. That range puts the Cardinals close enough to the number for a backdoor cover if Los Angeles controls the game but allows a late score. The 9.5-point line also sits well above the key number of 7.
Pick: Arizona Cardinals +9.5 (-110 at ESPN).
Cardinals vs Chargers Game Total Pick
Take the Under 47.5 points. The available projections mostly land between 37 and 47 combined points, with common scores such as Los Angeles 27-10 and 30-17 Arizona. That gives the Under a workable margin against the ESPN total.
The indoor setting removes wind and rain, but it also leaves the total dependent on execution rather than weather. Arizona's offensive line enters with Adams missing multiple practices, while the Chargers have Tuipulotu limited, making protection and third-down execution important factors for the scoring outlook.
These NFL predictions favor a controlled Chargers win rather than a shootout. The same trends in NFL team performance should be weighed with quarterback play and offensive line health before placing a wager, especially when the total is set at 47.5.
Pick: Under 47.5 (-110 at ESPN).
How to Watch Cardinals vs Chargers and Game Info
- Location: SoFi Stadium, Inglewood, CA
- Date: Sunday, September 13, 2026
- Kickoff: 4:25 p.m. ET
- TV: CBS
- Arizona Cardinals starting quarterback: Jacoby Brissett (TBD, TBD yards, TBD TD-INT).
- Los Angeles Chargers starting quarterback: Justin Herbert (TBD, TBD yards, TBD TD-INT).
- Weather forecast: 65°F, indoor conditions, no wind or rain.
Final Takeaways
The Chargers have the clear quarterback and home-field edge, but the 9.5-point spread is wide enough to make Arizona the better spread side. The NFL Picks are Chargers moneyline at -559, Cardinals +9.5 and Under 47.5. The strongest NFL predictions point to a Chargers win without needing a high-scoring game. Trends in NFL team performance should be paired with the current number before placing the wager.
All odds as of 7:27 a.m. ET on September 11, 2026. Odds sourced from ESPN. Check the latest odds and line movement for Arizona Cardinals vs Los Angeles Chargers at betting.net before placing your bets.