Rams at Bills Predictions, Odds and Betting Picks
Jesse M. Cox Published 12/10/2026
The Los Angeles Rams are 3.5-point favorites against the Buffalo Bills on Monday Night Football, but Buffalo's second-ranked scoring offense makes the spread more appealing than the home favorite's moneyline price. With the total set at 54.5 points, these NFL predictions focus on whether Josh Allen can exploit a Rams defense that has recorded only seven sacks.
The Rams average 417 yards per game, while Buffalo scores 31.8 points per game. This Statistical analysis of NFL teams points to a potentially competitive matchup, although Matthew Stafford's six interceptions create a turnover concern for Los Angeles.
Rams vs Bills Game Preview
Buffalo averages 31.8 points and 386.3 yards per game, giving Josh Allen a strong foundation even with wide receiver Joshua Palmer ruled out with a shoulder injury. Allen has thrown for 1,039 yards, six touchdowns and three interceptions, while running back James Cook has added 421 rushing yards on 70 carries. The Rams average 417 yards per game, and Stafford has passed for 1,189 yards with six touchdowns and six interceptions.
Buffalo will be without Ed Oliver and Joshua Palmer, while DJ Moore, Dee Alford and Rams safety Quentin Lake are questionable. Aaron Donald is listed as active despite missing practice, so confirm his status before kickoff. With SoFi Stadium indoors, weather will not affect these NFL Picks.
Rams vs Bills Moneyline Pick
The Buffalo Bills moneyline at +150 at bet365 is the underdog play. Buffalo averages 31.8 points per game, and Allen has thrown for 1,039 yards with six touchdowns. That production gives the Bills a credible path to an outright win against a Rams team averaging 21.2 points per game. These NFL predictions favor Buffalo's scoring ability at the available price.
Stafford's six interceptions against six touchdown passes create a concern for Los Angeles, especially against a Buffalo offense capable of scoring quickly. At +150 at bet365, a $100 wager would return $250 in total if the Bills win.
Pick: Bills moneyline (+150 at bet365).
Against the Spread Pick
Take the Buffalo Bills +3.5 at -115 at bet365. The extra half-point matters because a three-point defeat still cashes the ticket, while a loss by four points or more does not. Buffalo's 31.8 points and 386.3 yards per game give the offense enough production to keep the score close even if Los Angeles wins.
The Rams average 417 yards per game but have recorded just seven sacks. Buffalo's scoring ability should help keep the game close, making +3.5 a stronger NFL Pick than the moneyline.
Pick: Bills +3.5 (-115 at bet365).
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Rams vs Bills Game Total Pick
Take the Under 54.5 at -110 at bet365. The Rams average 21.2 points per game, and Stafford's six interceptions raise the risk of stalled drives or lost scoring chances. Buffalo averages 31.8 points, but the combined scoring average from the supplied figures is 53 points per game, below the posted total.
The Bills are also without Oliver and Palmer, affecting defensive line depth and receiving options. Those absences could create opportunities for Los Angeles, but a total of 54.5 still requires sustained scoring from both teams. The Statistical analysis of NFL teams supports a lean toward the Under rather than expecting both offenses to reach their best scoring levels. This is the total pick in our NFL predictions for Monday night.
Pick: Under 54.5 (-110 at bet365).
How to Watch Bills vs Rams and Game Info
- Location: SoFi Stadium, Inglewood, California
- Date: Monday, October 12, 2026
- Kickoff: 8:15 p.m. ET
- TV: ABC, ESPN
- Buffalo Bills starting quarterback: Josh Allen (record as starter: TBD, 1,039 passing yards, 6 touchdowns and 3 interceptions).
- Los Angeles Rams starting quarterback: Matthew Stafford (record as starter: TBD, 1,189 passing yards, 6 touchdowns and 6 interceptions).
- Weather forecast: Indoors, no weather factor.
Final Takeaways
Buffalo's scoring production and Stafford's turnover risk make the Bills the better value at +150 at bet365 on the moneyline, while +3.5 at -115 at bet365 offers more protection in a close game. The Under 54.5 at -110 at bet365 is the third pick, based on the Rams' 21.2 points per game and the combined scoring average of 53 from the supplied figures. These NFL Picks and NFL predictions favor Buffalo against the spread and a lower-scoring result, even if Los Angeles wins at home.
All odds as of 8:15 p.m. ET on October 12, 2026. Odds sourced from bet365, as reported by Canada Sports Betting. Check the latest odds and line movement for Bills vs Rams at betting.net before placing your bets.