Orioles at Cardinals Predictions, Odds and Betting Picks
Jesse M. Cox Published 26/08/2026
The Baltimore Orioles enter Wednesday as a -160 DraftKings moneyline favorite after opening the series with a 13-1 win over the St. Louis Cardinals. Kyle Bradish brings a 3.70 ERA and 129 strikeouts into the matchup, while Baltimore also has the clear form edge after scoring 13 runs Tuesday.
The biggest concern for Baltimore is Pete Alonso's calf. Alonso went 4-for-4 with a home run and four RBIs Tuesday before leaving early, while Tyler O'Neill remains day-to-day with a sore right shoulder. The Orioles still have enough offensive production to attack Michael McGreevy, who owns a 3.54 ERA but has allowed a .251 opponent batting average.
Orioles vs Cardinals Game Preview
Baltimore is coming off a 13-1 win and went 7-for-16 with runners in scoring position. The Orioles also won two of three against Tampa Bay from August 21-22.
ORIOLES vs. CARDINALS: Official Full Game Highlights (August 25) | 2026 MLB Season
St. Louis has dropped four straight, including losses of 6-4 and 12-3 to Philadelphia. The Cardinals are also without Hunter Dobbins and Andre Pallante, while Masyn Winn is dealing with a thumb injury. Kyle Bradish brings a 7-12 record, 3.70 ERA and 129 strikeouts. Michael McGreevy is 5-9 with a 3.54 ERA and 95 strikeouts. Busch Stadium should be 78°F to 81°F with light northwest winds of 5 to 7 mph.
Moneyline Pick
The Orioles ML is the pick. The Orioles are priced at -160 at DraftKings, and Bradish gives Baltimore the stronger starting-pitcher profile with a 3.70 ERA and 129 strikeouts. McGreevy has a solid 3.54 ERA, but St. Louis enters after allowing 13 runs Tuesday and has lost four straight.
A 13-run outburst in the series opener gives the lineup the recent offensive edge, with the team going 7-for-16 with runners in scoring position. Alonso's calf issue adds some uncertainty, but the surrounding bats provide enough depth to back the favorite.
Pick: Orioles ML (-160 at DraftKings).
Run Line Pick
The Orioles -1.5 is the run line pick. Tuesday's 13-1 victory produced a 12-run margin, while St. Louis has now lost four straight. The blowout also forced the Cardinals to use backup catcher Pedro Pages as a pitcher in the ninth inning. The standard -1.5 line gives Baltimore a path to cashing even if Alonso is unavailable, provided the Orioles' offense again creates separation against McGreevy and the Cardinals' relief corps.
Pick: Orioles -1.5 (Odds not provided at DraftKings).
Best Player Prop
- Kyle Bradish strikeouts Over 5.5 (Odds not provided at DraftKings). Bradish has recorded 129 strikeouts this season and enters with a 3.70 ERA across 138.2 innings. His strikeout total gives him a strong base for clearing a 5.5 line against a St. Louis lineup that has scored 4.4 runs per game this season.
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Game Total Pick
Under 8.5 runs is the pick. Bradish owns a 3.70 ERA and McGreevy carries a 3.54 ERA, giving Wednesday a much stronger starting-pitching matchup than Tuesday's game. The two starters have combined for 224 strikeouts, and both have held opposing hitters to a .252 or lower batting average.
The weather also does not create a major hitting boost. Busch Stadium is expected to be 78°F to 81°F with only 5 to 7 mph winds blowing out of the northwest. Baltimore scored 13 runs Tuesday, but that result came against Matthew Liberatore, who entered with a 5.04 ERA and allowed eight runs in four-plus innings.
Pick: Under 8.5 (Odds not provided at DraftKings).
Best Trades for Orioles vs Cardinals
The prediction market prices offer a much tighter view of the game than the DraftKings moneyline. Polymarket has Baltimore at 50¢ and St. Louis at 51¢, while the Orioles' -1.5 spread is priced at 39¢ and the Cardinals' +1.5 at 63¢.
- Orioles -1.5: NO at 63¢ on Polymarket. Baltimore is the DraftKings favorite at -160, but the 39¢ price on the Orioles to cover 1.5 runs shows traders are demanding a discount for a multi-run win.
- Run in the first inning: NO at 57¢ on Polymarket. Bradish owns a 3.70 ERA and McGreevy a 3.54 ERA, while Wednesday's 8.5-run total is much lower than Tuesday's 14-run game.
- Game winner: Orioles YES at 50¢ on Polymarket. The market price is far below Baltimore's -160 DraftKings moneyline, creating a major difference between the sportsbook price and prediction-market probability.
How to Watch Orioles vs Cardinals and Game Info
- Location: Busch Stadium, St. Louis, MO
- Date: Wednesday, August 26, 2026
- First pitch: 7:45 p.m. ET
- TV: Cardinals.TV Presented by bet365, MASN.
- Orioles starting pitcher: Kyle Bradish (7-12, 3.70 ERA).
- Cardinals starting pitcher: Michael McGreevy (5-9, 3.54 ERA).
- Weather forecast: 78°F to 81°F, mostly clear to partly cloudy, northwest wind at 5 to 7 mph.
Final Takeaways
Bradish gives the Orioles the edge with 129 strikeouts and a 3.70 ERA against a Cardinals team that has lost four straight. The offense scored 13 runs Tuesday, but Alonso's calf injury remains a concern after he left following a 4-for-4 performance. The best overall angle is the Orioles moneyline, while the prediction market prices them at 50¢ compared with -160 at DraftKings. The Under 8.5 also has support from the starters' 3.70 and 3.54 ERAs.
Check the latest odds and line movement for Orioles vs Cardinals at betting.net before placing your bets. All odds as of 1:03 a.m. ET on August 26, 2026. Odds sourced from DraftKings and Polymarket.