Brewers at Cubs Predictions, Odds and Betting Picks
Jesse M. Cox Published 31/08/2026
The Brewers enter Wrigley Field as +104 underdogs at DraftKings, but the pitching matchup gives Milwaukee a strong case against the Cubs. Kyle Harrison brings a 2.79 ERA and 127 strikeouts into Monday's game, while Chicago's Colton Holmes owns a 2.26 ERA but has a 5-6 record.
The total is set at 9.5 runs, with the Under priced at -120 at DraftKings. Milwaukee is 7-3 over its last 10 games, and the Cubs are dealing with several pitching injuries, giving this matchup a clear focus on starting pitching, bullpen depth and run prevention.
Brewers vs Cubs Game Preview
The Brewers are the preferred side at Wrigley Field, where they enter as +104 underdogs against the Cubs at -112 on DraftKings. The biggest edge starts with the mound. Milwaukee sends Kyle Harrison to the hill with a 10-3 record, a 2.79 ERA and 127 strikeouts, while Chicago counters with Colton Holmes, who is 5-6 with a 2.26 ERA and 55 strikeouts.
CUBS vs. BREWERS: Official Full Game Highlights (June 26) | 2026 MLB Season (Jacob Misiorowski)
Milwaukee has also been the better team over the past 10 games, going 7-3 heading into this four-game series. The Brewers are 85-52 overall, while the Cubs are 77-60. Chicago has a significant gap to close in the NL Central, and its lineup will need to produce against a left-handed starter who has already piled up 127 strikeouts this season.
Both teams are dealing with important injuries. Milwaukee expects reliever Abner Uribe to return after completing his rehab assignment, while Jake Bauers is day-to-day with shin splints. Chicago remains without Dansby Swanson because of a side and oblique strain, while its pitching depth has taken hits from injuries to Ben Brown, Edward Cabrera, Justin Steele, Shelby Miller, Gavin Hollowell and Hunter Harvey. The forecast at Wrigley calls for 83°F to 84°F, partly cloudy skies, a 22% chance of rain and southwest winds of 6.5 to 8 mph.
Moneyline Pick
Brewers ML is the side at +104. Milwaukee is getting plus-money treatment despite sending Harrison to the mound with a 2.79 ERA, 127 strikeouts and a 10-3 record. The Brewers have also won 7 of their last 10 games, giving them the stronger recent form entering a matchup where the market has priced the teams almost evenly.
The Cubs have the home-field advantage, but Chicago's pitching depth has been weakened by multiple injuries. Harrison's strikeout ability gives Milwaukee a way to control the game early, while the return of Uribe gives the Brewers another potential late-inning option.
The price is also important. Chicago sits at -112 on DraftKings, so Milwaukee only needs to win the game outright to cash the moneyline. At +104, the Brewers provide the better price for a team with a 13-game advantage in the overall record and a 7-3 mark over its last 10 games.
Pick: Brewers ML (+104 at DraftKings).
Run Line Pick
Brewers -1.5 is the run line side at +152. Milwaukee offers a substantial plus-money price despite Harrison's 2.79 ERA and 10-3 record. The Cubs have several injured pitchers, including Brown, Steele, Miller, Hollowell and Harvey, which puts more pressure on the available arms behind Holmes.
The Brewers are listed at +152 to win by at least two runs on DraftKings, compared with -184 for Chicago +1.5. That is a wide price gap on a standard 1.5-run line. If Harrison delivers a strong start and Milwaukee reaches the Cubs' bullpen early, the Brewers have a clear path to covering the larger margin.
Pick: Brewers -1.5 (+152 at DraftKings).
Best Player Prop
- Kyle Harrison strikeouts Over 6.5 (-110 at DraftKings). Harrison has 127 strikeouts this season and owns a 2.79 ERA across his 10-3 record. Chicago's lineup now has to handle a left-handed starter with enough strikeout production to reach seven Ks, making this the strongest individual player market in the matchup.
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Game Total Pick
Under 9.5 is the total pick. The two announced starters give this game a strong foundation for a lower-scoring result. Harrison enters with a 2.79 ERA, while Holmes has an even lower 2.26 ERA, and neither number supports expecting a quick offensive explosion from the opening innings.
The pitching depth on both sides also makes the first five innings especially important. Harrison has 127 strikeouts, while Holmes has 55, and both starters have ERAs below 3.00. Milwaukee is also expected to get Uribe back, giving the Brewers another relief option as they try to protect a lead.
The weather does not provide a major reason to push toward the Over. The forecast at Wrigley Field calls for 83°F to 84°F, partly cloudy conditions, a 22% chance of rain, and southwest winds of 6.5-8 mph. The total is 9.5 at DraftKings, and the Under is priced at -120, making the lower-scoring side the preferred play.
Pick: Under 9.5 (-120 at DraftKings).
How to Watch Brewers vs Cubs and Game Info
- Location: Wrigley Field, Chicago, IL
- Date: Monday, August 31, 2026
- First pitch: 7:40 p.m. ET
- TV: Marquee Sports Network, Brewers.TV Presented by Potawatomi Sportsbook.
- Brewers starting pitcher: Kyle Harrison (10-3, 2.79 ERA).
- Cubs starting pitcher: Colton Holmes (5-6, 2.26 ERA).
- Weather forecast: 83°F to 84°F, partly cloudy, southwest wind at 6.5 to 8 mph.
Final Takeaways
The Brewers are the preferred side because Kyle Harrison has posted a 2.79 ERA with 127 strikeouts this season, while Milwaukee is priced as a +104 underdog at DraftKings. The Cubs have the home-field advantage at Wrigley Field, but their pitching staff has been hit by several injuries, while Milwaukee has Uribe nearing a return. The best overall angles are Brewers ML, Brewers -1.5 at plus money, Harrison Over 6.5 strikeouts, and Under 9.5 runs.
Check the latest odds and line movement for Brewers vs Cubs at betting.net before placing your bets. All odds as of 3:12 a.m. ET on August 31, 2026. Odds sourced from DraftKings.