Rams Vs Cardinals: Betting Picks and Odds for NFL Week 9 Matchup
Jesse M. Cox Published 13/11/2026
The Los Angeles Rams are 9.5-point road favorites against the Arizona Cardinals in Sunday's NFC West matchup at State Farm Stadium. Los Angeles enters with a three-game winning streak, while Arizona will start rookie quarterback Carson Beck after injuries and roster changes left the team without its previous options at quarterback.
The Rams also have a major concern at wide receiver, with Puka Nacua ruled out and Davante Adams sidelined. Still, Matthew Stafford has thrown for 2,374 yards and 16 touchdowns this season. These NFL predictions focus on whether Los Angeles can cover the spread and whether both teams' offensive injuries will keep the total below 39.5 points.
Rams vs Cardinals Game Preview
The Rams enter Week 10 on a three-game winning streak at 5-4. Stafford has 2,374 yards, 16 touchdowns and nine interceptions. Arizona is 3-6 and will start rookie Beck after Brissett was traded and Minshew landed on injured reserve.
Both teams have key injuries. Nacua is out for Los Angeles, while Arizona has lost Wilson for the season and center Froholdt remains in concussion protocol. Rams lineman Avila also missed practice with a hamstring issue. Arizona upset Los Angeles in Week 6, and State Farm Stadium's retractable roof removes weather concerns. These NFL predictions also factor in the teams' depleted receiving options.
Rams vs Cardinals Moneyline Pick
Take the Los Angeles Rams moneyline at -520. Stafford gives Los Angeles a clear advantage over a rookie making his first NFL start, especially with Arizona missing experienced quarterback options. ESPN Analytics also gives the Rams a 78.7% win probability, compared with 21.1% for the Cardinals.
Arizona's offense averages 19.8 points per game, ranking 26th in the league. The Rams produce 23.8 points per game and rank fourth with 379.8 total yards per game. Although -520 is an expensive price, the quarterback difference and offensive production support Los Angeles. These NFL Picks favor the road team to secure another win.
Pick: Los Angeles Rams ML (-520 at DraftKings).
Against the Spread Pick
Take the Arizona Cardinals +9.5 at -108. The Rams are the stronger team, but a spread of more than one touchdown is difficult to justify with Nacua and Adams unavailable. Los Angeles also has several defensive and offensive starters dealing with injuries, which creates additional concerns about its ability to win by a wide margin.
Arizona averages 31:57 in time of possession per game, ranking fourth in the NFL. That gives the Cardinals a path to shorten the game and limit Stafford's opportunities. The Rams' three-game winning streak supports their chances of winning, but Beck does not need to lead an upset for Arizona to cover. A late score can also help the Cardinals stay within the number.
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Pick: Arizona Cardinals +9.5 (-108 at DraftKings).
Rams vs Cardinals Game Total Pick
Take the Under 39.5 at -112. Arizona averages only 19.8 points per game, while Los Angeles averages 23.8. Both offenses have important receiving injuries, and the Cardinals will rely on Beck in his first professional start.
The Rams have recorded seven interceptions this season, ranking ninth in the league, while Arizona has thrown only three interceptions as a team. However, Beck's limited NFL experience presents a different challenge against an NFL defense. The missing receivers on both sides also reduce the available passing options. This statistical analysis of NFL teams supports a lower-scoring game, making the Under the preferred total.
Pick: Under 39.5 (-112 at DraftKings).
How to Watch Rams vs Cardinals and Game Info
- Location: State Farm Stadium, Glendale, AZ
- Date: Sunday, November 15, 2026
- Kickoff: 4:05 p.m. ET
- TV: CBS
- Los Angeles Rams starting quarterback: Matthew Stafford (6-3, 2,374 yards, 16-9 TD-INT).
- Arizona Cardinals starting quarterback: Carson Beck (0-0, 0 yards, 0-0 TD-INT).
- Weather forecast: Indoors, no weather factor.
Final Takeaways
The Rams have the quarterback advantage, better offensive production and a three-game winning streak, making them the stronger moneyline option. However, Arizona's ability to control possession and Los Angeles' missing receivers make the 9.5-point spread difficult to cover. The best NFL predictions for this matchup are Rams moneyline, Cardinals +9.5 and Under 39.5. Bettors should prioritize the Under and Arizona's spread value when considering these NFL Picks.
All odds as of 4:04 a.m. ET on November 13, 2026. Odds sourced from DraftKings. Check the latest odds and line movement for Los Angeles Rams vs Arizona Cardinals at betting.net before placing your bets.