Dolphins Vs Colts: Betting Picks and Odds for NFL Week 10 Matchup
David Genge Published 11/11/2026
The Indianapolis Colts are the stronger side against the Miami Dolphins in their Week 10 matchup on Sunday, November 15. DraftKings lists Indianapolis at -135 on the moneyline and -2.5 against the spread, with Miami priced at +115. Miami's quarterback situation is a major concern after Malik Willis landed on injured reserve, leaving rookie Kyle McCord to make his first regular-season NFL start.
The Colts also have a more productive offense, averaging 20.4 points per game compared with Miami's 15.8. These numbers support the Indianapolis side in our NFL predictions, while Miami's limited scoring makes the Under an appealing option. Here are our NFL Picks for all three major betting markets.
Dolphins vs Colts Game Preview
Miami enters Week 10 with a 1-7 record, while Indianapolis sits at 2-7. The Dolphins average 282.3 yards per game and rank 31st in scoring at 15.8 points. McCord takes over at quarterback after Willis recorded 1,396 passing yards, six touchdowns and six interceptions. Daniel Jones remains Indianapolis' starter despite throwing 1,722 yards, six touchdowns and 10 interceptions this season.
Both teams have important injury concerns heading into Sunday. Miami will be without defensive tackle Zach Sieler for the rest of the season, while wide receiver Caleb Douglas and guard Jonah Savaiinaea are questionable. Indianapolis has wide receiver Alec Pierce on injured reserve, with tight end Mo Alie-Cox, offensive tackle Jalen Travis and linebacker Jaylon Carlies listed as questionable. The game takes place at Lucas Oil Stadium, which has a retractable roof and removes most weather concerns if closed.
Dolphins vs Colts Moneyline Pick
The Indianapolis Colts moneyline at -135 is the pick. DraftKings gives the home team a reasonable price against a Miami offense averaging just 15.8 points per game. McCord's first NFL regular-season start adds another challenge for a Dolphins team that has struggled to produce consistent offense.
Indianapolis also has a clear advantage in the running game. Jonathan Taylor has recorded 656 rushing yards and eight touchdowns, while Miami's Ollie Gordon II has 463 yards and four scores. Taylor's production gives the Colts a reliable option to control possession and reduce pressure on Jones. Our NFL Picks favor Indianapolis to secure the home victory.
Pick: Colts ML (-135 at DraftKings).
Against the Spread Pick
Take Indianapolis Colts -2.5 (-110). The Colts have a better scoring average and a stronger time-of-possession profile, averaging 31:10 per game compared with Miami's 28:46. That difference gives Indianapolis more opportunities to control the clock and build a scoring advantage.
The Dolphins also rank 31st in defensive sacks with only 12, while Indianapolis has recorded 19. Although Miami has five interceptions compared with the Colts' two, the Dolphins' limited pass rush remains a concern. At just 2.5 points, Indianapolis does not need a large winning margin to cover. This statistical analysis of NFL teams supports the home favorite.
Pick: Colts -2.5 (-110 at DraftKings).
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Dolphins vs Colts Game Total Pick
Take the Under 40.5. Miami averages 15.8 points per game, while Indianapolis produces 20.4, giving the teams a combined scoring average of 36.2 points. Both offenses rank outside the top 20 in total yards, with Miami averaging 282.3 and Indianapolis producing 288.9 yards per game.
Miami's quarterback change is another important factor. McCord has no regular-season NFL starting experience, and the Dolphins are also missing Willis and Sieler. Indianapolis should rely on Taylor's 656 rushing yards to manage the game rather than force Jones into a high-volume passing performance. These Trends in NFL team performance favor a lower-scoring contest, making the Under our preferred total.
Pick: Under 40.5 (odds not provided by DraftKings).
How to Watch Dolphins vs Colts and Game Info
- Location: Lucas Oil Stadium, Indianapolis, IN.
- Date: Sunday, November 15, 2026
- Kickoff: 1:00 p.m. ET
- TV: CBS
- Miami Dolphins starting quarterback: Kyle McCord (0-0, 0 passing yards, 0-0 TD-INT).
- Indianapolis Colts starting quarterback: Daniel Jones (2-7, 1,722 passing yards, 6-10 TD-INT).
- Weather forecast: Indoors, no weather factor.
Final Takeaways
Indianapolis has the stronger offensive numbers and a more dependable running game heading into this Week 10 matchup. Miami's quarterback change and limited scoring production make the Dolphins difficult to trust against a home team with a more balanced attack. Our final NFL predictions are Colts moneyline (-135), Colts -2.5 (-110), and Under 40.5. Bettors should prioritize the Colts against the spread and consider the Under based on both teams' scoring averages.
All odds as of time not provided ET on November 11, 2026. Odds sourced from DraftKings. Check the latest odds and line movement for Miami Dolphins vs Indianapolis Colts at betting.net before placing your bets.