Cowboys Vs Colts: Betting Picks and Odds for NFL Week 8 Matchup
Jesse M. Cox Published 03/11/2026
The Dallas Cowboys are six-point road favorites against the Indianapolis Colts in their Week 10 matchup on Sunday, November 8, 2026. DraftKings lists Dallas at -270 on the moneyline, while the spread is Cowboys -6 (-110) and the game total is 51.5 (-110 on both sides). Daniel Jones' nine interceptions and Indianapolis' league-worst -11 turnover differential create major concerns for the home team.
Dallas holds the offensive edge, averaging 27.4 points per game against Indianapolis' 20.1. Dak Prescott has 14 touchdowns and five interceptions, making the Cowboys the stronger pick in these NFL predictions. The Colts may still cover the spread, while the Under remains an option given their scoring struggles.
Cowboys vs Colts Game Preview
The Dallas Cowboys averages 342 yards and ranks seventh in scoring at 27.4 points per game. Prescott has 2,046 passing yards, 14 touchdowns and five interceptions. Indianapolis ranks 26th in total offense with 291.1 yards per game, while Jones has thrown for 1,542 yards, five touchdowns and nine interceptions. These numbers support the Cowboys in these NFL predictions.
Both teams have injury concerns. Dallas safety Caleb Downs and tight ends Jake Ferguson and Luke Schoonmaker are questionable, while George Pickens has shoulder and hamstring issues. Indianapolis has Alec Pierce on injured reserve, Ashton Dulin out with an ankle injury and DJ Giddens questionable. Lucas Oil Stadium's retractable roof removes weather concerns, making the NFL Picks more dependent on the teams' performances than outdoor conditions.
Cowboys vs Colts Moneyline Pick
The Dallas Cowboys moneyline at -270 is the pick with DraftKings. Prescott has thrown 14 touchdowns against five interceptions, while Jones has recorded five touchdowns and nine interceptions. That difference gives Dallas a clear advantage at quarterback, especially against an Indianapolis defense that has recorded only two interceptions.
ESPN Analytics gives Dallas a 61.2% chance of winning, supporting the Cowboys' position as road favorites. Indianapolis also ranks last in turnover differential at -11, creating another problem against a Dallas offense averaging 27.4 points per game. The -270 price is expensive, but the Cowboys have the more productive passing attack and a stronger overall scoring profile.
Pick: Dallas Cowboys ML (-270 at DraftKings).
Against the Spread Pick
Take the Indianapolis Colts +6 at -110 with DraftKings. Dallas is the stronger team, but Indianapolis can lose by five or fewer and still cover. Its ability to control possession gives the Colts a path to keeping the game close.
Indianapolis averages 32:02 in time of possession, ranking fifth in the NFL. Dallas ranks 28th at 28:45, giving the Colts an advantage in controlling the clock and limiting scoring chances. The spread also sits on the key number of six, meaning a Dallas win by exactly six results in a push. These NFL Picks favor Indianapolis because of its backdoor cover potential. Even if Dallas controls the game, a late Colts score could keep the margin within six points.
Pick: Indianapolis Colts +6 (-110 at DraftKings).
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Cowboys vs Colts Game Total Pick
Take the Under 51.5 points at -110 with DraftKings. Indianapolis averages just 20.1 points and 291.1 yards per game, ranking 26th in both categories. Daniel Jones' nine interceptions also create problems for an offense struggling to sustain drives.
The Cowboys averages 27.4 points per game, but Indianapolis leads in time of possession at 32:02 compared with 28:45. Longer drives can limit total possessions and scoring opportunities, supporting the Under. This Statistical analysis of NFL teams favors a lower-scoring game. Indianapolis' limited offense and turnover issues make the Under 51.5 the stronger choice among these NFL Picks.
Pick: Under 51.5 (-110 at DraftKings).
How to Watch Cowboys vs Colts and Game Info
- Location: Lucas Oil Stadium, Indianapolis, IN.
- Date: Sunday, November 8, 2026
- Kickoff: 1:00 p.m. ET
- TV: FOX
- Dallas Cowboys starting quarterback: Dak Prescott (record as starter: TBD, 2,046 yards, 14-5 TD-INT).
- Indianapolis Colts starting quarterback: Daniel Jones (record as starter: TBD, 1,542 yards, 5-9 TD-INT).
- Weather forecast: Indoors, no weather factor.
Final Takeaways
Dallas has the quarterback advantage and a stronger scoring offense, making the Cowboys the preferred moneyline selection. These NFL predictions favor Dallas ML at -270, while Indianapolis +6 offers a better opportunity against the spread because of its ability to control possession. The Under 51.5 is also the preferred total, given the Colts' average of 20.1 points per game. These NFL Picks are supported by the difference in offensive production, quarterback efficiency and possession numbers.
Check the latest odds and line movement for Dallas Cowboys vs Indianapolis Colts at betting.net before placing your bets. All odds as of 3:30 a.m. ET on November 3, 2026. Odds sourced from DraftKings.