Colts Vs Jaguars: Betting Picks and Odds for NFL Week 8 Matchup
David Genge Published 30/10/2026
The Jacksonville Jaguars are 7.5-point favorites against the Indianapolis Colts in their AFC South matchup on Sunday, November 1. DraftKings lists Jacksonville at -395 on the moneyline, while the game total sits at 46.5 points. The Jaguars' league-leading run defense and Indianapolis' recent roster losses create a difficult matchup for Daniel Jones and the Colts offense.
Jacksonville allows just 3.23 yards per carry, making it a tough opponent for Jonathan Taylor, who leads Indianapolis with 587 rushing yards and eight touchdowns. The expected rain and wind also create concerns for both passing attacks. These NFL Picks favor Jacksonville on the moneyline and spread, while the Under is the preferred total.
Colts vs Jaguars Game Preview
The Colts enter Week 8 with 22 points per game and 298 yards per game, ranking 20th and 25th in the league, respectively. Jones has thrown for 1,398 yards, four touchdowns and seven interceptions, while Trevor Lawrence has produced 1,480 yards, 14 touchdowns and four interceptions for Jacksonville. The Jaguars average 25.7 points and 347.7 yards per game, giving them a clear statistical advantage.
Indianapolis traded left guard Quenton Nelson and defensive tackle DeForest Buckner. Wide receiver Alec Pierce and cornerback Cam Taylor-Britt are on IR, while Bryce Boettcher and Justin Walley have missed practices. Jacksonville will also miss tackle Anton Harrison, while safety Antonio Johnson has been absent from practice. Wind gusts of up to 24 mph and possible thunderstorms add another concern.
Colts vs Jaguars Moneyline Pick
The Jacksonville Jaguars moneyline at -395 is the pick. Lawrence has thrown 14 touchdowns against four interceptions, compared with Jones' four touchdowns and seven interceptions. Jacksonville also holds a major advantage in turnover differential, ranking third at +5, while Indianapolis sits last at -9.
The Colts lost Nelson, while Jacksonville allows just 3.23 yards per carry, limiting Taylor's impact. Despite the -395 price, Lawrence's better numbers and Jacksonville's turnover advantage support the pick in these NFL predictions.
Pick: Jacksonville Jaguars ML (-395 at DraftKings).
Against the Spread Pick
Take Jacksonville Jaguars -7.5. Jacksonville averages 25.7 points per game, while Indianapolis allows a scoring gap with just 298 yards per game. The Colts' -9 turnover differential also creates problems against a Jaguars defense with seven interceptions.
The 7.5-point spread requires an eight-point win. Jacksonville's defensive advantage and Indianapolis' turnover struggles support the pick and strengthen these NFL Picks and NFL predictions.
Pick: Jacksonville Jaguars -7.5 (odds not provided by DraftKings).
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Colts vs Jaguars Game Total Pick
Take the Under 46.5 points. Indianapolis averages 22 points per game, while Jacksonville allows only 17.3 points per game based on its supplied scoring totals. The Jaguars' strong run defense also limits Taylor, potentially forcing Jones into more passing situations against a defense that has recorded seven interceptions.
Weather provides another reason to favor a lower-scoring game. Forecasts call for showers and thunderstorms, temperatures around 73°F to 74°F, and winds of 12 to 15 mph with gusts reaching 24 mph. Those conditions can affect passing accuracy and field-goal attempts, making the Under the stronger option in these NFL Picks.
Pick: Under 46.5 (odds not provided by DraftKings).
How to Watch Colts vs Jaguars and Game Info
- Location: EverBank Stadium, Jacksonville, Florida.
- Date: Sunday, November 1, 2026
- Kickoff: 1:00 p.m. ET
- TV: CBS
- Indianapolis Colts starting quarterback: Daniel Jones (record as starter: TBD, 1,398 yards, 4-7 TD-INT).
- Jacksonville Jaguars starting quarterback: Trevor Lawrence (record as starter: TBD, 1,480 yards, 14-4 TD-INT).
- Weather forecast: 73°F to 74°F, showers and thunderstorms likely, wind from direction TBD at 12 to 15 mph, with gusts of 22 to 24 mph.
Final Takeaways
Jacksonville has the stronger quarterback numbers, a better turnover differential and the league's top-ranked run defense. Those advantages make the Jaguars the preferred side in this AFC South matchup, especially with Indianapolis missing key players after its recent trades. These NFL predictions favor Jacksonville ML at -395 and Jaguars -7.5, both at DraftKings, with the Under 46.5 as the total pick. These Expert betting tips for NFL games point to Jacksonville controlling the matchup while poor weather adds pressure to both passing attacks.
Odds attribution: All odds as supplied for October 30, 2026. Exact capture time not provided. Moneyline and spread sourced from DraftKings. The game total is 46.5; its Over/Under prices were not provided. Check the latest odds and line movement for Indianapolis Colts vs Jacksonville Jaguars at betting.net before placing your bets.