Broncos Vs Cardinals: Betting Picks and Odds for NFL Week 7 Matchup
Jesse M. Cox Published 23/10/2026
The Denver Broncos are 4.5-point road favorites against the Arizona Cardinals, but their offensive struggles make the game total the key betting angle. DraftKings Sportsbook lists the total at 43.5 points, while Arizona running back Jeremiyah Love is expected to miss the game with an ankle injury.
Denver enters Week 7 at 4-2 after an overtime win over Seattle. Arizona is 2-4 following an 18-16 road upset of the Los Angeles Rams. These NFL predictions focus on Denver's defensive edge, the spread, and a low-scoring game.
Broncos vs Cardinals Game Preview
Denver averages 19 points per game and 252.2 yards, ranking 26th and 31st, respectively. Quarterback Bo Nix has completed 60.3% of his passes for 1,049 yards, six touchdowns, and three interceptions. Arizona averages 21 points and 307.3 yards per game, while Jacoby Brissett has thrown for 1,328 yards, nine touchdowns, and six interceptions.
Injury concerns affect both teams ahead of Sunday. Arizona's Jeremiyah Love, Budda Baker, and Walter Nolen III missed practice, while Denver's Pat Surtain II and Jaylen Waddle were limited participants. State Farm Stadium has a retractable roof, removing outdoor weather as a major factor. Denver's 18 sacks rank fourth in the NFL, while Arizona has recorded 14.
Broncos vs Cardinals Moneyline Pick
The Denver Broncos moneyline at -230 is the pick at DraftKings Sportsbook. Denver has a 68.9% win probability according to ESPN Analytics, and its defense leads this matchup with 18 sacks and seven interceptions. That pressure gives the Broncos an advantage against an Arizona offense led by Jacoby Brissett, who has thrown for 1,328 yards, 9 touchdowns, and 6 interceptions this season.
Brissett's six interceptions are a major concern against a Denver defense ranked fourth in sacks and second in interceptions. The Broncos also enter at 4-2 after an overtime win over Seattle, while Arizona sits at 2-4 despite its 18-16 upset of the Rams. At -230, a $230 wager returns $100 in profit if Denver wins, plus the original stake. The price is steep, but Denver's defensive edge and Arizona's turnover risk support the moneyline pick.
Pick: Denver Broncos ML (-230 at DraftKings Sportsbook).
Against the Spread Pick
Take the Arizona Cardinals +4.5 at -110 at DraftKings Sportsbook. Arizona averages 21 points per game compared with Denver's 19, giving the home team a path to stay within one score even if the Broncos control the defensive matchup.
The 4.5-point spread gives Arizona room to lose by a field goal or four points and still cover. Denver's offense averages only 252.2 yards per game, which makes a comfortable win less certain. These NFL Picks favor Arizona to cover, even though Denver remains the moneyline choice.
Pick: Arizona Cardinals +4.5 (-110 at DraftKings Sportsbook).
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Broncos vs Cardinals Game Total Pick
Take the Under 43.5 at DraftKings Sportsbook. Denver averages 19 points per game, while Arizona averages 21, producing a combined average of 40 points. Both offenses sit outside the top 20 in scoring, supporting the Under.
Denver's 18 sacks and seven interceptions also give its defense ways to disrupt Arizona's drives. The Cardinals are dealing with injuries to Love, Baker, and Nolen, while Nix has thrown three interceptions in six games. This statistical analysis of NFL teams supports a lower-scoring contest, regardless of the indoor conditions.
Pick: Under 43.5 (-105 at DraftKings Sportsbook).
How to Watch Denver Broncos vs Arizona Cardinals and Game Info
- Location: State Farm Stadium, Glendale, Arizona.
- Date: Sunday, October 25, 2026
- Kickoff: 4:05 p.m. ET
- TV: CBS
- Denver Broncos starting quarterback: Bo Nix (TBD, 1,049 yards, 6-3 TD-INT).
- Arizona Cardinals starting quarterback: Jacoby Brissett (TBD, 1,328 yards, 9-6 TD-INT).
- Weather forecast: Indoors, no weather factor.
Final Takeaways
Denver's defensive production makes it the moneyline choice, but its low offensive output gives Arizona a solid chance to cover +4.5. The three NFL predictions are Denver on the moneyline, Arizona against the spread, and Under 43.5 points. These NFL Picks rely on Denver's pass rush and the scoring limits shown by both teams' averages. Bettors should compare prices before placing wagers with a real-money sportsbook.
Check the latest odds and line movement for Denver Broncos vs Arizona Cardinals at betting.net before placing your bets. All odds as of 12:15 a.m. ET on October 23, 2026. Odds sourced from DraftKings Sportsbook.