Cardinals Vs Rams: Betting Picks and Odds for NFL Week 6 Matchup
Jesse M. Cox Published 16/10/2026
The Los Angeles Rams are 12.5-point favorites against the Arizona Cardinals on Sunday, October 18, according to DraftKings. Arizona allows 32.4 points per game, while Los Angeles averages 424.4 yards of offense, creating a major mismatch in a game with a 51.5-point total.
These NFL Picks focus on the Rams' offensive production, Arizona's defensive struggles, and the risk of backing a large favorite at a steep price. These NFL predictions also consider the potential for a high-scoring game, with expert betting tips for NFL games pointing to Los Angeles' offensive advantage and Arizona's defensive weaknesses. The game is indoors at SoFi Stadium, removing weather concerns from the betting equation.
Cardinals vs Rams Game Preview
Arizona enters Week 6 with a 1-4 record, averaging 21.6 points and 301.2 yards per game. Quarterback Jacoby Brissett has thrown for 1,110 yards, nine touchdowns and five interceptions, while Matthew Stafford has recorded 1,572 yards, nine touchdowns and six interceptions for the 2-3 Rams. Los Angeles averages 23.8 points per game and leads the league with 424.4 yards per game, a key factor in the statistical analysis of NFL teams for this matchup.
Arizona's rookie running back Jeremiyah Love has missed multiple practices with an ankle injury, while James Conner remains on injured reserve. The Rams will be without suspended left tackle Alaric Jackson, and tight end Davis Allen missed practice with a foot injury. Los Angeles is also coming off an overtime loss to Buffalo, while the fixed roof at SoFi Stadium eliminates outdoor weather as a factor.
Cardinals vs Rams Moneyline Pick
Take the Los Angeles Rams moneyline at -850 at DraftKings. Stafford has produced 1,572 passing yards, and the Rams' league-leading 424.4 yards per game give them a clear offensive advantage against an Arizona defense allowing 32.4 points per contest. These NFL Picks favor Los Angeles to win outright based on the difference in offensive production.
The price is expensive, requiring an $850 wager to profit $100. Arizona's +575 moneyline offers a larger payout, but Brissett's five interceptions and the Cardinals' defensive problems make the upset difficult to justify. These NFL predictions favor the Rams to win, although the short return limits the appeal of their moneyline.
Pick: Los Angeles Rams ML (-850 at DraftKings).
Against the Spread Pick
Take the Arizona Cardinals +12.5 at DraftKings, although the spread odds were not provided. The Rams have the stronger offense, but covering a margin of nearly two touchdowns is a challenge, especially after their overtime loss to Buffalo. Arizona averages 21.6 points per game, giving the Cardinals a chance to stay within the spread if Jacoby Brissett limits turnovers.
The 12.5-point line also gives Arizona room to cover with a late score. Los Angeles averages 23.8 points per game, making the Cardinals the preferred spread option in these NFL Picks and expert betting tips for NFL games.
Pick: Arizona Cardinals +12.5 (spread price not provided at DraftKings).
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Cardinals vs Rams Game Total Pick
Take the Over 51.5 points at DraftKings, with the total price not provided. Arizona allows 32.4 points per game, and Los Angeles averages 23.8 points, giving the Rams a favorable matchup against a struggling defense. Their 424.4 yards per game also create opportunities for sustained drives and scoring chances.
The Cardinals average 21.6 points per game, putting the teams' combined average at 45.4, below the 51.5 total. However, Arizona's defensive struggles favor the Over, despite Love's injury and Conner's absence. These NFL predictions back a high-scoring game led by the Rams' offense.
Pick: Over 51.5 (total price not provided at DraftKings).
How to Watch Arizona Cardinals vs Los Angeles Rams and Game Info
- Location: SoFi Stadium, Inglewood, California
- Date: Sunday, October 18, 2026
- Kickoff: 4:05 p.m. ET
- TV: FOX
- Arizona Cardinals starting quarterback: Jacoby Brissett (record as starter: TBD, 1,110 passing yards, 9-5 TD-INT).
- Los Angeles Rams starting quarterback: Matthew Stafford (record as starter: TBD, 1,572 passing yards, 9-6 TD-INT).
- Weather forecast: Indoors, no weather factor.
Final Takeaways
The Rams average 424.4 yards per game, while Arizona allows 32.4 points. These NFL Picks favor Los Angeles on the moneyline, Arizona +12.5 against the spread, and Over 51.5 points. The Rams have the offensive edge, but covering the 12.5-point spread remains a challenge.
All odds as of October 16, 2026. The exact odds timestamp was not provided. Odds sourced from DraftKings. Spread and total prices were not provided in the supplied game information. Check the latest odds and line movement for Arizona Cardinals vs Los Angeles Rams at betting.net before placing your bets.