Seahawks at Broncos Predictions, Odds and Betting Picks
David Genge Published 12/10/2026
Seattle has the stronger offensive numbers heading into Thursday Night Football, but Denver's pass rush makes this matchup more competitive than the moneyline suggests. The Seahawks are listed at -148 on the moneyline, -2.5 against the spread, and the game total is 42.5 points, based on the supplied odds.
These NFL predictions center on Seattle's scoring advantage and Denver's injury concerns in the secondary. The Seahawks average 26.8 points per game, compared with Denver's 19.4, while cornerbacks Patrick Surtain II and Riley Moss remain uncertain after missing Week 5. Those factors shape the best NFL Picks across the moneyline, spread, and total markets.
Seahawks vs Broncos Game Preview
Seattle averages 26.8 points and 328 yards per game, giving its offense a statistical advantage over Denver's 19.4 points and 269 yards. Quarterback Sam Darnold has thrown for 755 yards, seven touchdowns, and five interceptions, while rookie Bo Nix has recorded 942 passing yards, six touchdowns, and three interceptions. These numbers are central to the statistical comparison behind the NFL predictions for Thursday night.
Denver's secondary is banged up, with Patrick Surtain II and Riley Moss uncertain and Talanoa Hufanga ruled out with an ankle injury. Seattle's Zach Charbonnet is also unlikely to return. Denver's home advantage and altitude add another factor to these NFL predictions.
Seahawks vs Broncos Moneyline Pick
Take the Seattle Seahawks moneyline at -148, according to the supplied odds. Seattle's 26.8 points per game gives it a clear scoring advantage over Denver's 19.4, and the Seahawks have recorded seven interceptions compared with Denver's five. That turnover advantage gives Seattle another path to win if the Broncos struggle to protect the football.
At -148, a $148 bet would earn $100 in profit if Seattle wins. Denver's secondary injuries favor Seattle's passing game, making the Seahawks a strong moneyline pick based on their scoring and turnover advantages.
Pick: Seattle Seahawks ML -148.
Against the Spread Pick
Take the Denver Broncos +2.5 at the supplied spread. Denver's 13 sacks give its pass rush a chance to disrupt Darnold, who has thrown five interceptions against seven touchdowns. If Denver forces Seattle into long third downs and limits explosive plays, the Broncos can keep the final margin within a field goal.
The 2.5-point spread sits just below the key NFL number of three, meaning Denver bettors lose their full wager if the Broncos lose by a field goal. Still, Denver's home advantage and ability to generate pressure make it a reasonable spread choice despite Seattle's stronger offense. These Trends in NFL team performance support Denver covering the spread even if Seattle wins the game.
Pick: Denver Broncos +2.5.
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Seahawks vs Broncos Game Total Pick
Take the Under 42.5 points. Denver averages only 19.4 points and 269 yards per game, so its offense has less room for error against a Seattle defense that has recorded 14 sacks and seven interceptions. If the Broncos struggle to sustain drives, their scoring output may not be enough to push the game over the total.
Denver's 13 sacks also create a difficult matchup for Darnold, whose five interceptions show that turnovers are a concern. While Seattle averages 26.8 points per game, the Under has a path to cash if Denver's offense remains below its usual scoring level and both pass rushes disrupt drives. Among these NFL predictions, the total is based on the combined effect of Denver's lower offensive output and the pressure both defenses can generate.
Pick: Under 42.5.
How to Watch Seattle Seahawks vs Denver Broncos and Game Info
- Location: Empower Field at Mile High, Denver, Colorado
- Date: Thursday, October 15, 2026
- Kickoff: 8:15 p.m. ET
- TV: Prime Video
- Seattle Seahawks starting quarterback: Sam Darnold (record as starter: TBD, 755 passing yards, 7-5 TD-INT).
- Denver Broncos starting quarterback: Bo Nix (record as starter: TBD, 942 passing yards, 6-3 TD-INT).
- Weather forecast: TBD. Historical mid-October temperatures are around 50°F to 59°F, with clear skies possible. The game is outdoors in Denver.
Final Takeaways
Seattle's scoring advantage makes the Seahawks moneyline the preferred winner pick, while Denver's 13 sacks give the home team a path to cover +2.5. The Under 42.5 also fits the gap between Seattle's 26.8 points per game and Denver's 19.4. These NFL Picks reflect the central Trends in NFL team performance, while the NFL predictions favor Seattle to win a competitive game without expecting a high-scoring finish.
All odds as of 2:11 a.m. ET on October 11, 2026. Check the latest odds and line movement for Seattle Seahawks vs Denver Broncos at betting.net.