New York Jets at Detroit Lions Predictions, Odds and Betting Picks
The Detroit Lions are 6.5-point home favorites over the New York Jets for Week 3, with a 48.5-point total. Detroit has scored 31 points per game through two weeks, while Jared Goff has six touchdown passes without an interception, making the Lions' offense the main betting angle.
The Jets enter at 1-1 after a 20-17 overtime loss to Green Bay, but their defense has produced six sacks and a +2 turnover differential. These NFL Picks focus on Detroit's explosive offense, New York's ability to control possession and a Lions secondary that remains short-handed.
Jets vs Lions Game Preview
Both teams are 1-1 after two games, but Detroit has produced more offense. The Lions average 362 yards and 31 points per game, while Goff has 533 passing yards and six touchdowns. Geno Smith has 462 passing yards and one touchdown for New York, while Breece Hall has 131 rushing yards and Garrett Wilson has 136 receiving yards.
Injuries are key to this matchup. The Jets expect to miss Minkah Fitzpatrick with a groin injury, while Detroit remains without Brian Branch and Kerby Joseph. Avonte Maddox is also out for the season after foot surgery.
The situational setup also favors a high-output game. Detroit is playing at Ford Field, where the game will be indoors, and both teams have already shown turnover production with a +2 differential each. For bettors comparing NFL predictions, the Lions' 31 points per game against New York's 20 points per game creates a clear contrast.
Jets vs Lions Moneyline Pick
Take the Detroit Lions moneyline at -335 at FanDuel Sportsbook. Detroit has the stronger quarterback production, with Goff throwing for 533 yards and six touchdowns without an interception through two games. Jahmyr Gibbs has also produced 208 rushing yards and two touchdowns, giving Detroit another way to attack New York.
The Lions are heavy favorites, but Detroit's 31 PPG and New York's defensive absences support the home side. For NFL Picks, the dome also removes weather concerns.
Pick: Lions ML (-335 at FanDuel Sportsbook).
Against the Spread Pick
Take the New York Jets +6.5 at -102 at FanDuel Sportsbook. The Jets have controlled the ball for 38:13 per game, the best figure listed in the supplied team data, and they held a 17-7 fourth-quarter lead against Green Bay before losing in overtime. That possession edge gives New York a path to keep the final margin below a touchdown.
The 6.5-point spread sits between 3 and 7. Detroit allows 35.5 points per game, compared with 18.5 for the Jets, making the points more appealing. These Trends in NFL team performance support taking New York rather than laying nearly a touchdown.
Pick: Jets +6.5 (-102 at FanDuel Sportsbook).
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Jets vs Lions Game Total Pick
Take the Over 48.5 at -115 at FanDuel Sportsbook. Detroit averages 31 points and 362 yards per game, while its defense has allowed 35.5 points per game. That combination gives this matchup a strong path to 49 or more points without requiring either offense to produce an unusually high total.
The Jets average 326 yards per game and have produced 20 points per game, while both teams have a +2 turnover differential. Detroit also has seven sacks compared with New York's six, but the Lions' secondary injuries give Smith and Wilson opportunities in the passing game. With Ford Field indoors, weather is not a factor in these NFL predictions.
Pick: Over 48.5 (-115 at FanDuel Sportsbook).
How to Watch New York Jets vs Detroit Lions and Game Info
- Location: Ford Field, Detroit, MI
- Date: Sunday, September 27, 2026
- Kickoff: 1:00 p.m. ET
- TV: FOX
- New York Jets starting quarterback: Geno Smith (TBD, 462 yards, 1-0).
- Detroit Lions starting quarterback: Jared Goff (TBD, 533 yards, 6-0).
- Weather forecast: Indoors, no weather factor.
Final Takeaways
Detroit's offense is the central angle, with 31 points per game and Goff's six touchdown passes leading the matchup. The NFL Picks are Lions ML (-335), Jets +6.5 (-102), and Over 48.5 (-115), all at FanDuel Sportsbook. The spread pick relies on New York's possession numbers and defensive scoring profile, while the total targets Detroit's scoring pace and its secondary injuries. These Expert betting tips for NFL games point to a Detroit win, a Jets cover and a game above 48.5 points.
All odds as of 3:20 AM ET on September 22, 2026. Odds sourced from FanDuel Sportsbook. Check the latest odds and line movement for New York Jets vs. Detroit Lions at betting.net before placing your bets.