Milwaukee Brewers at Cincinnati Reds Predictions, Odds and Betting Picks
David Genge Published 24/06/2026
The betting angle in this NL Central matchup starts with the Milwaukee Brewers' edge on both sides of the ball. The Brewers enter Wednesday averaging 5.3 runs per game, second in MLB, while the Cincinnati Reds rank 23rd in team ERA at 4.58 and have already allowed 103 home runs this season.
Milwaukee also brings one of baseball's most reliable pitching staffs into Great American Ball Park. The Brewers own a 3.45 ERA and a 1.19 WHIP through 76 games, while the Reds continue to play without key contributors including Elly De La Cruz and Hunter Greene.
Brewers vs Reds Game Preview
Milwaukee enters this game with a 47-29 record and one of the league's strongest run differentials. The Brewers have scored 397 runs this season and are hitting 0.256 as a team with a 0.340 on-base percentage. Their offense has produced 131 doubles and 68 home runs while consistently putting pressure on opposing pitching staffs.
BREWERS vs. REDS Full Game Highlights (6/23/26) | MLB Highlights
Cincinnati sits at 37-40 and continues to battle lineup concerns. The Reds have hit 96 home runs, but their 0.229 team batting average ranks among the weaker marks in the National League. The absence of Elly De La Cruz removes a major source of speed and power from the lineup.
The pitching matchup features Shane Drohan for Milwaukee and Rhett Lowder for Cincinnati. Drohan owns a 3.43 career ERA and 1.19 WHIP across 47.2 MLB innings. Lowder has posted a respectable 3.50 career ERA, but Cincinnati's bullpen behind him has converted only 54.5% of save opportunities and has already blown 15 saves this season.
Moneyline Pick
The Brewers are the side to back. Milwaukee holds clear advantages in offense, pitching depth, and bullpen performance. The Brewers average 5.3 runs per game compared to Cincinnati's 4.28, and their pitching staff owns a full run advantage in ERA at 3.45 versus 4.58. Those numbers have been consistent across nearly three months of play.
Drohan's limited MLB sample has been encouraging, allowing only 18 earned runs across 47.2 innings. Behind him is a staff that ranks third in baseball in ERA and has allowed only 72 home runs all season. Cincinnati's offense has already struck out 712 times, the fourth-highest total in MLB.
Pick: Brewers ML (-160 at DraftKings).
Run Line Pick
The Brewers -1.5 is the preferred run line play. Milwaukee has scored 72 more runs than Cincinnati this season and faces a Reds pitching staff carrying a 1.465 WHIP. Cincinnati has also used 275 relievers compared to Milwaukee's 225, suggesting a heavier workload on the bullpen. If Milwaukee's offense continues producing at its season average, the Brewers are positioned to create separation late.
Pick: Brewers -1.5 (+105 at DraftKings).
Best Player Prop
- Shane Drohan Strikeouts Over 4.5 (+110 at DraftKings). Cincinnati has struck out 712 times this season, the fourth-highest total in baseball. Drohan has recorded 47 strikeouts in 47.2 career innings and draws a Reds lineup missing one of its most dangerous hitters in Elly De La Cruz.
Up To $1500 in Bonus Bets Paid Back if your First Bet Does Not Win
+9
- 20+ sports available for wagering
- Pre-match and in-play betting
- Unique features like live streaming and boosted odds
Bet $10 Get $150 in Bonus Bets
Find out more on bet365's website
- Over 20 sports
- Extensive betting markets
- Live betting feature
New Users – Bet $5 Get $200 in Bet Reset Tokens for 5 Days
+6
- Deep market coverage across major U.S. sports and leagues
- Same Game Parlay builder is fast and easy to use
- Live betting interface updates quickly with real-time odds
Game Total Pick
Under 9 is the strongest total play. While Great American Ball Park is known for home runs, this number already accounts for that environment. Milwaukee's pitching staff enters with a 3.45 ERA and has surrendered only 257 earned runs all season. The Brewers also rank among the league leaders in limiting hard contact and home runs.
The Reds' offense has struggled for consistency, batting 0.229 with a 0.311 OBP. Cincinnati averages just 4.28 runs per game and remains without several key contributors. Lowder's 3.50 career ERA provides enough stability on the home side to help keep this game from becoming a slugfest.
Those looking through the latest sports betting app offers may find attractive prices on totals markets, but the Under remains the preferred position based on the available matchup data.
Pick: Under 9 (-110 at DraftKings).
Best Trades for Brewers vs Reds
Prediction market traders are pricing Milwaukee as a moderate favorite, but several contracts still offer actionable opportunities based on current team form and roster health.
- Game Winner, Milwaukee Brewers: YES at 57¢ on Polymarket. Milwaukee owns a 47-29 record, ranks second in MLB in runs scored, and brings a pitching staff with a 3.45 ERA into the matchup.
- Total Runs Under 9.5: YES at 52¢ on Polymarket. Milwaukee's pitching staff ranks third in baseball in ERA, while Cincinnati averages only 4.28 runs per game and continues to deal with lineup absences.
- Cincinnati Reds to Score First: NO at 56¢ on Polymarket. Shane Drohan enters with a 3.43 career ERA, and Milwaukee has consistently limited early scoring opportunities throughout the season.
How to Watch Brewers vs Reds and Game Info
- Location: Great American Ball Park, Cincinnati, Ohio
- Date: Wednesday, June 24, 2026
- First pitch: 7:10 p.m. ET
- TV: Reds.TV
- Milwaukee Brewers starting pitcher: Shane Drohan (3-2, 3.43 ERA).
- Cincinnati Reds starting pitcher: Rhett Lowder (5-6, 3.50 ERA).
- Weather forecast: TBD
Final Takeaways
Milwaukee enters this matchup with the stronger offense, the better pitching staff, and a sizable edge in overall consistency. The Brewers rank second in MLB in runs scored and third in team ERA, a combination that has fueled their 47-29 record. Cincinnati remains competitive at home, but injuries and bullpen concerns create a difficult path against one of the National League's most complete teams. The Brewers moneyline and Under 9 stand out as the best plays on the board.
All odds as of 12:00 PM ET on June 24, 2026. Odds sourced from DraftKings. Check the latest odds and line movement for Milwaukee Brewers vs Cincinnati Reds at betting.net before placing your bets.